Corporate benefits managers are charged with evaluating and choosing benefits packages that balance adequate coverage with cost-effectiveness. Insurance companies and benefits consultants often recommend cost-saving strategies that control patients’ access to healthcare services—practices known as utilization management (UM). However, UM can negatively impact outcomes for employees facing cancer and other serious illnesses.

The Employers’ Prescription for Employee Protection Toolkit: Best Practices for Prescription Drug Benefit Design is a comprehensive guide to help benefits managers, human resources professionals, and executives better understand UM. This toolkit will help you achieve a deeper understanding of UM practices and their unintended consequences on the health and well-being of your employees. The Toolkit also provides the tools you need to create a strong, patient-focused prescription coverage plan that can reduce your costs on the medical benefits side and increase employee productivity and satisfaction.

What's Included

Section 1 provides an introduction to UM and looks at how UM policies intersect with benefit design decisions that impact employers and employees alike. Alongside current research, you’ll find expert perspectives from HR executives, doctors and benefits consultants. The illustrated explainers provide a closer look at seven common UM practices and their consequences. Several are paired with Case Studies shared by patients who have experienced, firsthand, the negative consequences of UM practices.

A video series focusing on specific UM topics is designed to take these concepts and show how they work in the real world.

Section 2 brings together resources for working with benefits consultants and insurers to create a strong prescription coverage plan. It includes best practice recommendations to guide plan design and questions that will help employers evaluate health plan options and UM policies.

Explore the Toolkit

Section 1: About Utilization Management

  • An Overview of Utilization Management (UM)
  • The Role of Pharmacy Benefit Managers (PBMs)
  • Innovations in Cancer Care vs. UM
  • Working With Benefits Consultants
  • What Employers May Not Know
  • The Costs of UM to Employers
  • Common UM Practices & Consequences
  • Illustrated Explainers: Common UM Practices & Consequences
  • Case Studies
  • Videos

Section 2: Resources for Employers

  • Key Take-Aways for Benefit Design
  • Pharmacy Benefit Plan Recommendations
  • Request for Proposal (RFP) Questions to Ask

Glossary of Terms & Works Cited
Acknowledgements

Each year since its founding in 1944, CancerCare’s oncology social workers and financial navigators have spoken with thousands of people facing a cancer diagnosis. In the past few years, we have increasingly heard of the challenges our clients face in accessing their prescribed treatments because of their insurance plan restrictions.

We have created this guide, The Employer Toolkit, to address the impact of the roadblocks that are preventing patients from accessing the medications they so desperately need. Approximately 50% of Americans receive healthcare through their jobs, and those benefits are among the most important that an employer can offer its valued employees.

Many cost-saving measures seem benign but can cause great harm, particularly to those with cancer and other serious or chronic health conditions. In your efforts to control healthcare costs, it is important to ensure that the strategies you consider do not adversely impact your employees’ wellbeing. Looking at healthcare benefits holistically, however, helps to demonstrate how some cost-saving measures can actually increase overall healthcare costs and absenteeism, while also reducing productivity and causing other adverse consequences.

This Toolkit is designed to help explain the unintended consequences of increasingly common prescription drug cost control measures and offer recommendations on how to structure prescription drug benefits to protect your employees who need access to these medications. Several of our recommendations have become law in many states, which we believe supports the case for these measures. We approached this project from our perspective as a cancer organization, but the issues we highlight in this Toolkit apply to anyone facing a serious illness or dealing with a chronic condition.

We hope you will listen to the patients’ experiences featured in the Toolkit videos and help others – namely, your employees and their beneficiaries – avoid these or similar life-defining experiences, when facing a serious health problem.

Thank you.

Sincerely,

Patricia J. Goldsmith
Chief Executive Officer
CancerCare

Introduction

An Overview of Utilization Management (UM)

The Role of Pharmacy Benefit Managers (PBMs)

Innovations in Cancer Care vs. Utilization Management

Working With Benefits Consultants

What Employers May Not Know

The Cost of UM to Employers

Common Utilization Management Practices & Consequences

Common UM Practices & Consequences

Pre-authorization

Pre-authorization requires that certain medical services, treatments or prescriptions be approved by insurers before a patient can receive them. This process is supposed to control health care costs but can cause serious unintended consequences while not really saving money.

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What is pre-authorization?

  • In healthcare, pre-authorization (PA)—also called “prior authorization,” “prior approval,” and “pre-certification”—requires that certain services, treatments or prescriptions be submitted to the insurer for review and deemed medically necessary before the patient receives that care.23 Although intended to contain costs and protect patient safety,24 PA requirements can delay treatment, restrict access to medications or specialists and increase out-of-pocket costs for patients, who may ultimately abandon treatment.25

    Joanna Morales, a cancer rights attorney and CEO of Triage Cancer, describes how securing PA adds stress for cancer patients and their caregivers during an already difficult time. “While healthcare providers may assist with pre-authorizations, at the end of the day the burden is on the patient. If a patient doesn’t get pre-authorization for a drug or treatment they’ve received, the insurance company can refuse to cover it. Then the patient may have to pay the full cost of that care.” Morales points out that since there isn’t a set list of drugs or procedures that require PA, patients have to be vigilant and proactive in seeking it. “And the rub is that even when you get pre-authorization, payment isn’t guaranteed.” Morales has known of insurers telling patients that pre-authorization “was just temporary and we can change our mind.”

    An estimated 72-90% of all PA requests are approved, with additional approvals granted when patients appeal an initial denial.26,27 That sounds like good news at first. But given the delays and costs associated with PA, that high approval rate raises questions about what this process actually accomplishes. Unfortunately, the hassle of PA may be the point: some health plans use it as a deterrent or gatekeeper, knowing that even to get the care they need, many patients won’t pursue pre-authorization or appeal when it’s denied.

    “And the rub is that even when you get pre-authorization, payment isn't guaranteed.”


    - Joanna Morales
    Cancer rights attorney & CEO of Triage Cancer

    Many physicians report that PA policies are an obstacle to good patient care. According to the 2020 AMA Prior Authorization Physician Survey:

    • 90% said pre-authorization has a somewhat or significant negative impact on patient outcomes.
    • 94% reported that the process delays access to necessary care.
    • 79% reported that it led to patients abandoning their recommended course of treatment.
    • 30% reported that pre-authorization has led to a serious adverse event for patients in their care.

Pre-authorization & prescription drugs

  • Pre-authorization and prescription drugs

    Increasingly, insurers have targeted prescription drugs for pre-authorization as a cost-saving measure. What started as requirements for new, high-cost specialty medications has grown to include even established brand-name drugs and generics with no low-cost alternatives.28 For example, more than quarter of drugs covered by Medicare Part D plans required PA in 202129; in 2007, it was just 8%.

    Physicians typically can’t tell if a medication requires PA when they prescribe it: that info isn’t readily accessible, varies by health plan and changes often. Instead, physicians submit requests retrospectively, after the pharmacy flags a coverage issue.28,30 But that added step deters many patients: 37% of prescriptions flagged for PA are abandoned by patients at the pharmacy and never filled.31

    Treatment abandonment is one reason why PA is linked to worse health outcomes, increased hospitalizations and higher overall medical costs when it’s applied to drugs that treat diabetes, depression and other mental health conditions. These same serious and chronic illnesses—as well as cancer and multiple sclerosis—are now subject to PA requirements that cover entire disease states and classes of drugs under some health plans.28

Costs of pre-authorizations

  • Costs of pre-authorizations

    Medical practices expend significant resources to secure pre-authorizations. In the 2020 AMA survey, respondents reported an average of 40 pre-authorizations per physician, per week. The extra administrative work takes away from physicians’ time spent caring for patients and contributes to physician burnout, which reduces the quality of care.32 Some physicians avoid prescribing certain treatments, even when they’re beneficial, knowing that the PA process will be particularly cumbersome.25

    As practices struggle to cover higher administrative overhead due to the PA process, the costs come back to patients. “You might see on a bill where a physician charged $300 for a 20-minute visit, and you think, ‘How can that be?!,’ but very little of that is profit,” explains oncologist Len Lichtenfeld, MD. “The majority goes to the costs of running a medical practice, including the extra administrative staff and other office overhead needed to handle pre-authorizations. What we see now are large networks buying up smaller practices. These networks have a stranglehold on services in large cities and can go toe-to-toe with insurance companies to negotiate better reimbursement. But that comes at a cost to patients, directly and indirectly. It comes in higher insurance premiums, higher prices for service, higher copays.”

What does pre-authorization accomplish?

  • What does pre-authorization accomplish?

    Many physicians and patients experience an endless PA roller coaster. In a 2016 AMA survey, 80% of physicians reported they were frequently required to re-submit requests for on-going treatments that stabilize patients with chronic conditions, despite the finding that 72% of initial pre-authorization requests were approved.26 A study of dermatology clinics found the vast majority of biologic drug prescriptions were approved, yet the PA process cost clinics a median $15.80 per request and took as long as 31 business days.33 It begs the question: Should patients really wait a month for medications that are overwhelmingly authorized?

    Pre-authorization doesn’t save patients or employers money, and health economists question whether it actually saves health plans money either.

    In some cases, administrative costs to the insurer outweigh any cost savings and plans actually lose money.34

    Other studies have linked PA to increases in overall healthcare costs.35 In one, patients with Type 2 diabetes who were denied PA for newer medications had higher overall medical costs the following year, likely resulting from conditions that worsened without necessary drugs.36

    Calls for reform ask why the time-consuming, repetitive PA process can’t be streamlined to benefit all involved since reducing the administrative load could save time and money for patients, physicians and health plans alike.37 A standardized electronic approval process and real-time decisions on commonly approved items could help. Employers can address this by selecting or customizing health plans that relax PA requirements, particularly for chronic conditions and time-sensitive illnesses such as cancer.

    In response to this, under a recently passed Texas law, physicians will no longer be required to get prior authorization for common procedures or prescriptions where they have a 90% or better approval history.

Case study: Amy W.

  •      Amy W.
         Washington D.C. area
         Multiple myeloma
         Watch Amy tell her story »


    As a healthy and active 37-year-old, my world shattered when I was diagnosed with an incurable blood and bone marrow cancer, multiple myeloma. This rare cancer tends to be found in men aged 70 and over, so my situation was met with puzzled doctors and a poor prognosis.

    Myeloma creates holes in your bones, which has caused extraordinarily painful fractures in my spine, skull, pelvis and ribs. It is debilitating. I even had to learn to walk again when my spine collapsed. In order to afford healthcare, I continued to work full-time for many years, until last year, when I had to take disability as my work could not accommodate my treatment and fatigue-impacted schedule. Along the way, there were times when I just could not make it to work due to fatigue, feeling ill and pain. My cancer has also had a severe impact on my stamina and ability to have a social or family life—again from the fatigue, nausea and pain.

    Not only am I fighting a rare cancer, but I am also forced to deal with challenging policies, red tape and delays from insurance companies. Two stressful and dangerous insurance policies are pre-authorization and formulary restrictions. Formulary restrictions sometimes stop my insurance from covering the cost of the medications I have been relying on; pre-authorization can slow access to my medication, since new and/or additional specialists have to authorize my urgently needed drugs. Both of these policies have slowed my healing and possibly shortened my life expectancy by allowing my cancer more time to progress. They also end up costing the insurance company more money in the long run, as delays mean getting sicker, then having to battle back an even higher cancer load and thus needing even more medications to “dig out of the hole.”

    From the time I started treatment in 2008, I have been working with several doctors to determine the exact medication combination that is the most effective and tolerable. Sometimes my treatment has been oral chemotherapy, which can severely disrupt the balance of one’s stomach. Unfortunately, after determining a workable medication combination that allows me to function at a semi-decent level, my insurance sometimes changes its formulary restrictions. They decide to no longer cover the cost of my medications and shift the brunt of the costs onto me. When I could not pay these enormous fees, the insurance company would propose other medications that were different enough to throw off my medication regimen, which could mean ineffective chemotherapy. Some insurance substitutions were so dangerous for me that my doctor would not even allow me to take the substitution. So, I then must start all over again, all the while losing time in battling my cancer.

    My health is always in a precarious state as insurance companies fail to look at the big picture—they often use tactics such as formulary changes to lower their bills at the expense of patients like myself. The medication swaps that insurance companies suggest interact with my body and chemotherapy in a different way than my original prescription, and I need a specific combination of drugs to keep me functioning. Needing my precise original prescriptions, I have had to appeal and fight to keep my drugs and health. Both the appeals process and pre-authorization continue to get in the way of my healing and quality of life, including my ability to work. Appeals take countless hours from very sick patients who often do not have the stamina to fight. And, sadly, doctors are often not allowed to dispense medications they know could help because of the slow pre-authorization process. These obstacles have delayed my treatments too many times, which only shortens my days.

    As with most cancers, myeloma begins to evade treatments, causing urgent searches for new ones. I have gone through most FDA-approved treatments for my cancer, so the only hope for extending my life is successful medication developed in clinical trials. I, and my loved ones, participate in Cycle for Survival, where I have personally raised $90,000+ that goes directly to clinical trials for rare cancer. When I am not participating in these events, I am also advocating for better healthcare laws that serve and protect patients. At the end of the day, my life is hinged on these protective healthcare laws and medical trials, and I contribute so that others never have to go through what I have gone through.

Pre-authorization fact sheet infographic

Common UM Practices & Consequences

Formulary Design

A formulary is a list of drugs approved by a health plan, typically arranged into tiers. Plans often limit or change access to drugs for financial reasons, which can cause serious unintended consequences for patients.

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How do formularies work?

  • A formulary is a list of available drugs approved for use by a health plan. It is typically divided into tiers, which reflect the level of cost sharing required each time the prescription is filled—that is, how much of the drug’s price a patient will need to cover at the pharmacy counter as determined by their copay or coinsurance rate. The formulary is designed by insurers and pharmacy benefit managers (PBMs), who presumably examine the clinical outcomes associated with different medications and current treatment standards.38 Drug costs also play a significant role in formulary design, including rebate “paybacks” negotiated with drug manufacturers that generate profits for PBMs, but don’t necessarily lower costs for patients. It’s nearly impossible to determine the basis for a formulary design because there is no transparency in the process; there is no requirement that PBMs disclose how decisions are made, or how or when changes are made.

    Formularies can be open, restrictive or a mix of the two. An “open” formulary provides at least partial coverage for nearly all drugs, even if they’re not included on the preferred list. In a restrictive or “closed” formulary, the health plan only provides coverage for the limited number of drugs. If a prescribed treatment is not on its formulary, the insurer is unlikely to provide coverage and patients must pay costs in full.

    From 2014 to 2020, the number of medications excluded by at least one of the three major PBMs expanded by about 34% each year. In other words, patients are increasingly likely to discover “gaps” in their drug benefits and face significant out-of-pocket costs if they need to access a medication that is not on the formulary.39 While restrictive formularies have become a common UM tool, multiple studies have linked their use to increased medical costs and higher total healthcare spending.15 In contrast, studies of open formularies suggest better outcomes. For example, researchers modeled scenarios under different formulary structures for patients with HIV and found that all major outcomes, including survival rates and overall treatment costs, were significantly better in the open formulary scenarios.40

How are formulary tiers set?

  • PBMs set formulary tiers based on a drug’s approved use, (presumably) its efficacy and benefits, cost to patients, cost to the insurance company and cash-back rebates that manufacturers pay the PBM. Formularies include both brand-name drugs and generics—versions of brand-name drugs that sell at a lower cost, but have the same active ingredients, dosage, strength, safety, effectiveness and quality. Generally, generics and low-cost drugs appear in lower tiers, with brand-name treatments appearing in the higher tiers.

    Tier / Drug TypeDescriptionCost
    1 | Lowest Copay
    Usually Generic
    Most generic prescription drugs. Lowest copayment.$
    2 | Medium Copay
    Usually Preferred Brand-Name Drugs
    A PBM may give a drug preferred placement because it has negotiated cost-saving rebates from the manufacturer, in exchange for placement on a lower tier that drives a higher volume of use. These rebates are typically not passed along to the patient or employer.$$
    3 | High Copay
    Brand-Name
    Some of these brand-name drugs may have lower-priced generics on Tier 1 or 2.$$$
    4 | Highest Copay
    Specialty
    Drugs used for chronic and serious illnesses, including cancer.

    Instead of a flat copay, patients may be required to pay a percentage of a drug's total cost, which is called co-insurance.

    Alternatively, some employers designated Tier 4 for preventative care and remove any cost-sharing requirements.
    $$$$

    Typically, PBMs and insurers prefer that physicians prescribe Tier 1 medications as a first step, versus a more expensive brand-name drug from Tier 2 or 3. However, this isn’t always the case: some PBMs receive and pocket high-volume rebates for brand-name drugs in exchange for lower tier placement, so the brand-names may end up costing patients less than the comparable generics.

    Prescriptions for drugs that are not on formulary are usually denied coverage; patients need to pay the full cost or appeal to the insurer to include the drug, a time-consuming process that typically delays treatment and adds stress. Formularies vary by health plan and change over time, often without any transparency or notice to patients or clinicians. The same drug might be Tier 2 under one health plan and Tier 3 under another, or a drug’s tier position may change when a health plan changes its formulary.

The role of rebates

  • PBMs negotiate rebates from drug manufacturers in exchange for preferred placement of a brand-name drug on their formulary. Rebates are refunds that are paid to the pharmacy benefit manager by the drug manufacturer after the drug is sold—so the PBM’s final net price for the drug is lower than the original list price. PBMs may pass the rebates on to health plans; however, their contracts often allow them to keep a portion. Rebates are a major source of revenue for many PBMs.

    Mark Peters, PharmD, Vice President of New Business Development & Outreach at CancerCare, explains how rebates drive drug placement on formularies. “Some drugs have such large rebates that it’s very difficult for newer drugs in their class to get placed in the same formulary tier.” The new drug typically ends up placed at a higher tier rate, if it’s covered at all. “The PBM doesn’t want patients to use the new drug even if it’s a better remedy for them, because the rebates make the older drug so profitable.”

    Because rebate negotiations are not made public (in fact, they’re a closely guarded secret), it’s difficult to gauge if or how savings are passed on to patients or the employers who sponsor plans. Studies suggest the direct benefits to patients may be minimal. For example, a 2021 study found that changes in net drug prices—which reflect the savings to PBMs, post-rebate—were not correlated with changes in patient out-of-pocket spending. These studies concluded that rebates reduce PBM spending on drugs but aren’t directly passed on to patients.41 To address this, some policymakers have called for an end to confidential rebate negotiations; others propose a process that would apply rebates directly to the patient’s out-of-pocket cost when they pay for drugs.41

Generics, biosimilars & competitive pricing

  • The competitive advantage conferred by rebates has confounded conventional wisdom about brand-name vs. generic drug or biosimilar pricing. As described above, generic drugs are slight variations of a brand-name drug, marketed at a lower cost. Likewise, a biosimilar is a lower-priced alternative to a biologic drug (therapies developed from living cells that help boost the immune system’s response).

    Generics and biosimilars are intended to keep brand-name drug prices in check. In 1984, the Hatch-Waxman Act made it legal to promote price competition via generics once a brand-name drug’s patent protection runs out. The FDA has created a similar pathway to approval for biosimilar drugs.

    The rebate system, however, has turned the tables and distorted the market. For many years, insurers and PBMs steered patients towards generic or biosimilar options through their formulary tiers. Now, large PBMs are altogether excluding some generics and biosimilars from their formularies, despite their being effective and available at lower list prices, in favor of brand-name drugs that supply significant rebates.

    For example, Express Scripts, a PBM that handles benefits for 100 million Americans, gave preference to nine brand-name drugs and excluded their generics in a 2019 formulary change.

    The excluded generics included an insulin that was half the price of the brand-name and an asthma medication priced at a 70% discount to the brand-name price.42,43

    The fact that savings from generics weren’t appealing to this cost-focused PBM hints at the high profits it makes from brand-name rebates. Again, these savings are not necessarily passed on to patients; the rebate process and resulting exclusions effectively block patients from accessing the cheaper generic medicines because, to patients, they actually cost more out-of-pocket than the brand-name drugs.

    In cancer care, oral drug treatments have rapidly joined chemotherapy and biologic infusions as safe and effective cancer treatments. These drugs are usually covered as a pharmacy benefit, while infusion therapies typically fall under medical benefits. While the oral drugs offer numerous benefits, they often cost patients much more to access, due to the cost-sharing requirements in restrictive formulary designs. Proposed “oral parity” legislation (such as the Cancer Drug Parity Act of 2019) seeks to make oral medications as accessible to patients as infusions and remove barriers that health plans might implement to limit their use. This legislation requires a plan to cover self-administered anticancer medication at a cost no less favorable than the cost of IV, port-administered or injected anticancer medications. Parity laws have found major support among state governments. Especially important during the COVID-19 pandemic, oral therapies have allowed many patients to stay at home and avoid the potential virus exposure from in-person chemotherapy infusions. Oral therapies can also minimize the need for transportation and time off from work, thereby supporting increased productivity.

Mid-year formulary changes & non-medical switching

  • Formulary plans can change mid-year or at any other time, which leaves the insured, who often can only choose their health plan during open enrollment, with an unexpected cost or lack of access to treatments. Changes may reflect treatment advances or new findings, but changes also occur when PBMs negotiate lucrative new deals with drug manufacturers. Depending on negotiations, a treatment might replace another, receive a better tier placement or be eliminated entirely from a plan’s approved formulary. Many states and patients-rights advocates are fighting to prohibit arbitrary and unexpected formulary changes.44

    Changes to formulary coverage can result in non-medical switching, which occurs when changes are made in a patient’s treatment plan that are NOT prescribed by their doctor for medical reasons. For instance, non-medical switching can occur when an insurer completely eliminates coverage for a medication, moves a drug to a higher formulary tier that is unaffordable to the patient, or offers patients or pharmacists a financial incentive to switch to a preferred drug.

    A 2021 promotion from Cigna illustrates the last case: the insurer removed a widely used psoriasis drug from most of its formularies then offered patients a $500 debit card for agreeing to switch to a different medication.

    While Cigna framed the change as a cost-saving benefit to patients, physicians and advocacy groups decried the offer as “unethical,” “unconscionable” and “coercive” for “targeting patients and enticing them with a financial incentive, particularly during a pandemic, when finances and employment for many are uncertain.” They expressed concern that the move would disrupt long-standing relationships between physicians and patients and could jeopardize patient health if the new medication was not as safe and effective as the replaced drug.45

    It often takes doctors and patients months, or even years, to find the most effective medications to manage a patient’s cancer or other serious illness. When an employee loses access to a medication that has stabilized their condition, they can experience re-emerging symptoms, negative side effects or even a relapse of their illness. For patients using biologic and biosimilar cancer therapies that are precisely tailored to the genetics of their cancer, a switch in treatments can be especially precarious. This can also be the case for certain “quality of life” medications that don’t treat cancer, but rather treat medication side effects (like nausea) or long-term post-surgical effects.

    While formulary changes and non-medical switches are intended to reduce costs for a health plan, costs may actually increase over time from extra administrative work, more doctor appointments, additional laboratory work and more hospitalizations due to adverse effects and treatment failures.46,47 Formulary changes can also create higher out-of-pocket costs for patients, decreased work productivity and increased stress and anxiety. While some patients can make a more affordable switch, others may not have access to acceptable alternative medications and may abandon treatment altogether.

Case study: Non-medical switching, Patricia Goldsmith

  •      Patricia Goldsmith
         New York, New York
         Colorectal cancer
         Watch Patricia tell her story »


    In 2014, out of the blue, I was diagnosed with colorectal cancer. I was really lucky; I had great insurance, I had contacts at every cancer center in the country and my case was handled properly. But unfortunately, one of the consequences of my treatment was a very, very bad side effect: major gastrointestinal distress. And that can have a dramatic impact on anyone’s life. Thankfully, my physician prescribed a medication that worked. As time went on, we eventually determined a dosage that worked very effectively for me. It was a lower dosage than when I originally started on the drug; life was all good and I could continue my daily activities.

    One day, I received a notice from my pharmacy as I was trying to refill the medication: it was no longer covered—not on the formulary. Imagine my panic. I was fortunate enough that I had some stockpiled because the dosage had been reduced. My surgeon, my primary care physician, everyone went through all the appeals processes and United Healthcare / OptumRx said, “No.” So, my primary care physician suggested, “Trish, why don’t you just try what they’re substituting and see if it works. Try it for a month.” I agreed and went to the local Walgreens drive-thru to pick it up. I pulled up and the pharmacist said, “I’m sorry, you’re going to have to come inside, it’s too big to put in the drawer.” So I walked into the store and picked up a rather large box.

    It was slightly smaller than a breadbox. Inside were 180 small packets. The directions were to take six packets each day, mixing each individual packet with eight ounces of juice or water. The packets couldn’t be combined. This was not a regimen I could tolerate. Immensely frustrated trying to reach someone at OptumRx, I finally got a human being on the phone line. I said, “You have got to be kidding me about this.” And here’s the solution that was offered: “Well, you can mix the packet in applesauce.”

    Needless to say, this was not an acceptable option for me. I am a busy person and I didn’t have the time or patience to mix this medicine six times a day. Instead, I decided to take the original medication, which cost me $695 out of pocket per month. Then, about a year and a half ago, I got notification from OptumRx that my original medication was back on the formulary and that I could get it through mail order. My copay was about $60 a month, they would send three months’ worth and I thought, “This is great!”

    I waited two or three weeks and heard nothing. Then I got a letter that this medication was out of stock, but they had a substitute for me. Can you guess? The packets again. I went to my local Walgreens and asked my pharmacist if there was a shortage of my medication or a problem keeping it in stock. She said, “No, I have it in stock.” So I figured it’s just OptumRx’s way of trying to switch me to the less-expensive treatment.

    I still take the medication. If I run out, I’m back to the six-packets-a-day plan or the $695-a-month plan.

Formulary design & non-medical switching fact sheet infographic

Formulary design & value assessments

  • In recent years, PBMs have increasingly used value assessment frameworks to inform drug formulary design and their negotiations with drug manufacturers. Value assessments are economic frameworks applied to healthcare decisions to determine whether the benefits of a drug or treatment are worth the price being charged for it. Each framework comprises a number of factors, including efficacy, cost, benefits, risks and, sometimes, the larger impact on a group or society.48

    Value assessments are typically designed to average and summarize; this makes it challenging to apply them to individual needs and fails to acknowledge diverse circumstances among patients. As health economist Lisa Kennedy points out, current frameworks “aren’t reliable across the same patients over time, across different patients and, additionally, fall down when required to measure more difficult things such as [treatment value] in the elderly or the very young.”49 In addition, the formulas used to make these assessments aren’t always transparent.

    While framework design involves multiple stakeholders, patients are notably missing among them. Most value assessments fail to incorporate the diverse and dynamic ways patients think about value—for instance, the cancer patients who value treatments that will allow them to get back to work faster, return to exercising or playing piano, or to attend a grandchild’s graduation.

ICER & concerns regarding value assessments

  • An influential but controversial agent in value assessment is The Institute for Clinical and Economic Review (ICER), a private research organization, and its framework, the “incremental cost-effectiveness ratio.” While this framework has gained traction among insurers and PBMs, CancerCare and many leading medical organizations have criticized ICER’s methodology, citing its discriminatory “one-size-fits-all” models, lack of transparency and failure to incorporate real-world perspectives from patients, caregivers and physicians.50

    ICER only discloses the details of their assessment models to select stakeholders. This “black box” process makes it impossible for researchers to share methods, conduct peer reviews or attempt to replicate and validate results. The lack of transparency also hides the model’s underlying assumptions, limitations and gaps that can impact the relevance of its results for patients with even slightly different profiles.

    Without patient input, crucial perspectives on “value” are missing from ICER’s assessments. Value Our Health, a consortium of leading healthcare organizations, argues that ICER reduces the meaning of “value” to “cost-effective” only. The National Health Council’s Patient-Centered Value Model Rubric outlines the need for patient involvement at every stage of the value assessment process, from initial development to the sharing of results. Value assessments should consider multiple facets of patients’ lives and broader societal perspectives, such as a patient’s ability to work and caregiver burden.51,52

QALYs (Quality-Adjusted Life Year)

  • A primary concern regarding ICER is its use of a QALY standard in its value assessments. QALY stands for “Quality-Adjusted Life Year” and is an older economic tool used to quantify the net value of a treatment by determining how its cost corresponds to the potential benefit. The QALY model essentially creates a formula for “quality of life x length of life” that can be stated as a single number.

    In the ICER framework, one QALY is defined as one full year of perfect health and valued at roughly $100,000 to $150,000.

    ICER calculates a treatment’s “cost-per-QALY” and compares it against that $100,000-$150,000 threshold. Healthcare experts point out that this is “an artificial affordability threshold,”51 but one with very real consequences for patients when it’s applied by insurers and PBMs. For example, in 2018 CVS Caremark announced plans to adopt ICER frameworks for managing their drug formulary and would no longer cover drugs with a cost-per-QALY over $100,000. Consider the real people who would be denied medication because it is deemed that the value of their lives is capped at $100,000 a year. Their family would no doubt say that another year with their loved one is priceless.

    By design, the QALY’s narrow focus on “perfect health” devalues and discriminates against people due to their age, disabilities or chronic conditions. How these patients actually view their quality of life is not considered. For the many individuals who never meet the criteria for “perfect health,” ICER’s calculation credits them with only a percentage of a life-year. This makes it even harder to show a treatment is a “valuable” investment according to the QALY threshold. When QALYs are used to determine cost effectiveness for a drug formulary or other health plan coverage, the resulting decisions have the same discriminatory flaws and could lead policymakers and payers to conclude that certain treatments for seniors, patients with chronic conditions or people with disabilities are not worth covering.

    The Affordable Care Act bans the use of QALYs for creating Medicare drug formularies, building on similar prohibitions and civil rights protections established earlier through the Rehabilitation Act and Americans with Disabilities Act. As Patricia Goldsmith, Chief Executive Officer of CancerCare, noted, “The Medicare program has long barred the use of QALYs in reimbursement and coverage decisions, recognizing that this metric discriminates against people with cancer and other serious health conditions. It’s frustrating that state and federal policymakers continue to debate their use in public programs. Organizations representing millions of patients and people with disabilities demonstrate a united front against state and federal policies that use the QALY metric or import it through reference pricing.”

Case study: QALY-based value assessments, Chris & Michelle Bushell

  •      Chris & Michelle Bushell
         Calgary, Alberta, Canada
         Cystic fibrosis


    We are the parents of two sons afflicted with cystic fibrosis (CF), the most common fatal genetic condition. From the moment Zachary (age 19) and Brett (age 16) arrived in this world, we have never known for certain what tomorrow would bring, when the next 2:00 a.m. trip to Emergency Care would occur, or whether hours of chest therapy would reduce the discomfort of constant rasping and wheezing. For 19 years, we’ve lived daily with the prospect of potentially losing one, if not both, of our sons.

    Now imagine knowing that a life-saving drug is available for CF patients. Trikafta has changed the lives and long-term outlook for CF patients worldwide. It’s the silver bullet that can slay the CF monster and provide a chance at a normal life. Trikafta is approved for use and covered by insurance in most countries in the western hemisphere—except for our home country of Canada.

    This devastating reality is due to the use of QALY-based value assessments in Canada’s public health system, which fail to account for life-changing innovations, precision medicines and other high-cost specialty drugs. The review process is also excruciatingly slow: it took nearly five years from Health Canada approval for Trikafta’s predecessor to gain public healthcare coverage!

    Time is not on our side. These drugs are preventative: excessive delay or imposing funding conditions, such as patients needing to have low lung function, defeats the purpose of the drug and is inhumane. CF eats away at patients’ lungs each and every day.

    A few weeks before Christmas 2020, our oldest son, Zach, was hospitalized. He had been plagued with an unresponsive, highly resistant gram-negative bacteria for the past five years. During that time, he used colistin (the “antibiotic of last resort”) twice daily, converting an IV med into an inhalant to reduce the threat of this deadly bacteria. His lung function had dropped to just 40%. We thought the moment we had dreaded since his birth had arrived: CF was finally going to win.

    We were determined to get Trikafta for Zach no matter what. A clinic in the U.S. took the generous step of granting a virtual assessment and prescribed Trikafta on the condition that Zach was “in the process of moving” to the United States. Shortly afterwards, we took the COVID risk and flew to the United States for Zach’s first month’s supply.

    Three weeks later, after starting Trikafta, Zach’s lung function was 71% and his CF team in Calgary stopped his antibiotics. As parents that have been expecting the early death of a child, the feelings we had seeing those results were nothing less than euphoric. Today, Zach’s lung function continues to climb and the resistant bacteria that had plagued him are gone. He’s gaining weight and the abdominal pain he’s suffered his whole life is gone.

    Trikafta (or its successor) is a drug that Zach will have to be on for the rest of his life. The reality is that, in order to keep receiving it and the care he needs, we’ve had to send Zach to live in the United States. Zach has a U.S. passport; he was born in California while we were working there as expats. But he grew up in Canada; our family is Canadian. As Canadians, we’re still anxiously waiting for Trikafta to be available to our younger son, Brett. It’s painful to see our boys separated not only by miles, but by the opportunity for a healthier life. We’ve agreed to share this private part of our lives because we feel obligated and determined to help Brett and other Canadian CF patients.

QALY-based value assessments fact sheet infographic


QALY, which stands for "quality adjusted life year," is a controversial metric used to assess whether the cost of a treatment corresponds to the potential benefits to the patient, but its design discriminates against older people and those with chronic conditions.

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Common UM Practices & Consequences

Step Therapy

Step therapy is a protocol that forces patients to try one or a series of drugs before being allowed the drug prescribed by their clinician. Patients can endure weeks or months of delay while taking less effective, or even harmful treatments, which can be devastating for people with cancer or other serious conditions.

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What is step therapy?

  • Step therapy, sometimes referred to as a “fail-first” protocol, requires patients to use treatments on lower formulary tiers (usually generics or preferred drugs that provide cost-savings to the insurer or larger rebates to the PBM) before being approved for drugs in higher tiers or, in some cases, drugs not included in the formulary. Patients and their physicians must demonstrate that the required treatment has “failed” before the insurer will authorize coverage for the treatment originally prescribed.

    The step therapy approach is intended to address the rapidly rising costs of healthcare by lowering or maintaining costs for the insurer and the patient. “Lower costs” may only apply to the PBM and insurer, however; for patients, step therapy can mean added out-of-pocket expenses, as well as significant burdens on their time and well-being.

Concerns regarding step therapy

  • Concerns regarding step therapy

    While encouraging the use of generic or lower-cost alternatives may sound positive, step therapy is a flawed system that can put patients at risk. Some insurers even require patients to “re-try” drugs that already failed or worsened their condition in the past. As health policy expert Robert Popovian, PharmD, MS, notes, “There is no empirical evidence that step therapy reduces overall healthcare costs and [offers] improvements in patient outcomes short or long term. Insurers or PBMs and their clinical staff have never explained what it means to fail. Should a patient suffer from worsening disease symptoms or side effects, or maybe be hospitalized? Insurers and PBMs also unnecessarily demand that providers justify every single intervention they utilize, through mounds of paperwork.”53

    Delayed, disrupted and denied treatment due to step therapy causes serious harm in the time-sensitive fight against cancer and other aggressive diseases. It can also cause serious side effects and major setbacks in managing chronic illnesses, as well as significant impacts on employee productivity and presenteeism.

    For example, Virginia Maxwell and her son have pityriasis rubra pilaris (PRP), an auto-immune disorder that causes inflammation and scaling of the skin, which can lead to bleeding sores and infection. While Virginia can successfully manage her PRP with an injectable drug, the family’s health plan required her son to try other treatments first before he, too, could be approved for the injectable medication. This approach resulted in a deteriorating condition so severe that he missed school and suffered extreme pain and discomfort.54

    Expensive cancer drugs are often targets of step therapy. Yet many oncology drugs do not have substitutes that are both equally effective and less costly. When cancer patients don’t get the right drug at the right time, the length of illness can increase.55 One study found that breast cancer patients who endured a three-month or more delay in treatment had a 12% lower five-year survival rate. The uncertain process of waiting for lesser drugs to fail can take weeks or months. Additionally, step therapy has been shown to reduce the long-term effectiveness of treatment.56

    Advances in treatment may outpace coverage decisions, putting step therapy out of sync with best practices.

    For example, in 2019 the FDA approved a new first-line treatment for patients with advanced renal cell carcinoma.

    Many step therapy protocols, however, still require an older drug be tried first, based on outdated guidelines—even though updated research indicates far better outcomes with the newer medication.

The true cost of “saving” money

  • Studies show that the money insurers save through step therapy comes at the expense of patients’ health and financial well-being.

    The step therapy process pushes some patients to abandon beneficial drug treatment. A 2009 study looked at patients with bipolar disorder who were required by insurance to use pre-authorized drugs in place of the medications prescribed by their clinicians. Initially, the use of the pre-authorized drugs showed a cost savings to the health plan. But a closer look at the data revealed the “savings” corresponded to patients who stopped treatment altogether when faced with a different medication than what their doctor prescribed.57

    Step therapy can also create unexpected out-of-pocket costs for patients, since they are required to pay a copay for the pre-authorized drug and then another copay once the drug preferred by their doctor is finally approved. In addition, some plans require the use of brand-name drugs that are on a formulary’s lower tiers due to the bigger rebates their manufacturers offer. While PBMs and insurers profit from these rebates, patients in high deductible plans may end up burdened with the full out-of-pocket costs associated with a brand-name drug’s higher price. It’s well known that higher out-of-pocket costs are associated with increased rates of treatment abandonment.

    The use of step therapy can also result in loss of income, lost time at work or in school and other social and economic burdens. One study looked at data from employers who implemented step therapy and compared it to employers who did not, to understand the effects of step therapy on patients taking antihypertensive drugs. Initial results showed a reduction in costs from the step therapy group; over time, however, there was a marked increase in those patients’ healthcare costs, due to hospital and emergency room visits. In other words, step therapy may create barriers to effective care, which ultimately results in worsening health and higher treatment costs, as well as presenteeism and reduced productivity.

    The practice of step therapy has been condemned by the American Medical Association, the American Society of Clinical Oncology and other leading medical organizations.

    Critics argue that step therapy prevents doctors from making treatment decisions based on clinical information and puts centralized cost-saving policies ahead of patients’ specific needs. Others note that step therapy takes too narrow a view of what constitutes “cost,” ignoring long-term costs for care and the physical and emotional costs levied on patients.

    The proposed Safe Step Act would place federal restrictions on step therapy and create a streamlined process for patients and their healthcare providers to request exceptions. Among its restrictions, the Act would protect patients from having to re-try treatments that previously failed or try new treatments when a prescribed drug has stabilized their condition. As of August 2021, 29 states have already passed laws limiting or regulating step therapy.

Case study: Step therapy, Justin Williams

  •      Justin Williams
         Atlanta, Georgia
         Polymyocitis
         Watch Justin tell his story »


    In 2015, I was an average 28-year-old until I woke up on my bathroom floor after passing out unexpectedly. That moment changed the course of my life. I scheduled a doctor’s appointment, where several tests were run that ultimately led to my diagnosis of polymyositis, an inflammatory disease that causes severe muscle weakness.

    The tests showed extremely high levels of creatine kinase (ck)—my number was off the charts. For reference, my test said my levels was 6752 when the average levels are between 24.0 - 204U/L. High levels of creatine kinase indicate muscle deterioration. My doctor was thrilled that I had come in so quickly after experiencing my symptoms so we could attack the disease immediately. Other symptoms had shown themselves that I wasn’t so quick to notice: I couldn’t lift things over my head, I couldn’t do push-ups, I was barely able to get myself out of bed and I was having trouble swallowing liquids and most food.

    Immediately upon my diagnosis, my doctor knew what to prescribe: a rituximab infusion. The infusion would only have to be done once every two years and would significantly reduce my ck levels. I have health insurance through my employer, but they denied the claim. The insurance has a step therapy policy that forces patients to try less effective, cheaper medication before the pricier, effective drug.

    I was prescribed the next best option, prednisone. In addition to the prednisone, I was put on seven other medications to balance out the intense side effects caused. My face swelled up, my body was so inflamed that I couldn’t sleep for more than two hours a night, and I became extremely irritable. My job was in jeopardy because I was so unlike myself. I couldn’t think clearly and had to cut my workload. I was like a zombie.

    After about six months of hardly sleeping and dealing with these difficult side effects, it got to a point where I was crumbling. There was one day when I found myself suffering from shortness of breath and felt a panic attack coming on. This drove me to check into the hospital for a second time, where the doctor said I had what is known as “athlete heart syndrome”. This is when the heart never really has a chance to rest; it’s always working at full capacity. It’s extremely dangerous and can contribute to further issues down the line.

    It was clear the prednisone wasn’t working. I started out on a high dosage of the prednisone, but extensive time on a high dose will cause other issues. Over time, I dropped to 10 mg with little success in my levels and several other health challenges. At this point, my healthcare team requested my insurance to cover the infusion once again. They finally approved it after months of suffering.

    Upon my first infusion of rituximab, my ck levels started to drop significantly. It wasn’t until about four to five months later that I began to feel relief from my symptoms. I’m now at the lowest creatine levels I’ve seen: 484. I have continued to get the infusion every two years and it has helped. I only wish I never had to go through the step therapy process at the beginning; that was one of the most challenging times of my life. Thankfully my mother, Gabrielle Jones, was by my side and fighting along with me every step of the way.

Step therapy fact sheet infographic

Case study: Step therapy, Heidi Barrett

  •      Heidi Barrett
         Everett, Washington
         Psoriatic arthritis


    I suffer from psoriatic arthritis. I also have five children and a husband, all of whom have at least one auto-immune disease. Our family receives health insurance through my husband’s employer and I only recently have been able to return back to work, which was critical due to the rising cost of my family’s medical care. I am a family law paralegal.

    All of our family members who suffer from this disease had been on a medication we found successful: Remicade. It falls under a class of drugs called “biologics.” We sort of have a “science experiment” going on within our family, where one person tries a medication, finds success, and the others follow suit. Without this drug, my family would be in wheelchairs from our pain and may not even be alive.

    The insurance provider denied the medication, despite the knowledge that it would help me. Enforcing a policy called step therapy, the insurance company forced me to try other, cheaper medications first. If those medications “fail,” the insurance company will then approve the more expensive, effective medication. Of course, these medications do fail and it results in extra hospital visits, vomiting, pneumonia and strep throat while the patient is on them. Eventually, I received approval for Remicade and reached a point where I had worked my way up to a high dose, which had been truly helpful for me.

    Out of nowhere, our health insurance decided they no longer wanted to pay for this life-saving medication and pulled it out from under me, citing expenses. They said I could restart the Remicade at a low dose, as part of step therapy. That was not an option for me because biologics like Remicade can cause life-threatening drug interactions if they are reintroduced at a low dosage. It’s extremely dangerous and not recommended. Our hands were tied.

    My only option was switching to a drug called Simponi, which is about 80% as effective as Remicade. This turned out to be the lesser of two evils, so we had to move forward with it. Unfortunately, my dose wasn’t enough to compensate for my symptoms, and if I were to get the infusion as frequently as needed to compensate for the reduced efficacy, it would cost $6,000 out of pocket each time. I was in so much pain when I first switched to Simponi that I barely left the house and even had to use a cane for about six months. Had our insurance decided to continue my care and cover the high dose of Remicade, I could have avoided this severe pain and suffering.

    Step therapy, while there may be a time and place for it, really isn’t beneficial to those of us who are hurting and need specific medications to live daily life. Doctors, administrators and pharmacists who have no experience treating specific diseases are calling the shots and determining the pre-authorizations required for certain medications. We need specialized experts determining what medications are best for treating our individual cases.

    Not only have we had to deal with bankruptcy due to the restrictions in our health insurance plan, but step therapy has caused additional, unnecessary painful days for our family and has put us in life-or-death situations. I only fear what will happen to my younger children when they turn 26 and have to navigate these scary insurance policies on their own.

Common UM Practices & Consequences

Specialty Pharmacies

What are specialty pharmacies?

  • Specialty pharmacies focus on medications for complex, chronic or rare medical conditions, including cancer. These drugs require extra care to dispense safely. They may need temperature-controlled storage or special handling, delivery by injection or infusion, or on-going patient monitoring. For cancer patients, specialty pharmacies can help coordinate the shipment of chemotherapeutics and the logistics of how they’ll be administered.

    While there is no official licensure to designate specialty pharmacies, some seek accreditation from independent organizations, such as the Center for Pharmacy Practice Accreditation or the Accreditation Commission for Health Care, to demonstrate their high quality of care. Not all specialty pharmacies offer the same level of patient support. While some specialty pharmacies increase access to treatment, others serve as an extension of insurers’ restrictive utilization management practices.

Why do insurers use specialty pharmacies?

  • Since the 1990s, the rise of new specialty drugs—and their costs—has turned once-niche specialty pharmacies into a growing industry. Their services have attracted insurance providers, pharmaceutical benefit managers and drug manufacturers who see the profit potential. Insurers and PBMs negotiate contracts with, own or control specialty pharmacies to serve as designated providers for their health plans. The pharmacy agrees to reimbursement rates that are more profitable for the insurer or PBM, in exchange for access to a larger pool of patients. On the other side of the supply chain, some drug manufacturers set up contracts that grant a few pharmacies exclusive access to carry their products, helping to control pricing and ensure safe delivery of sensitive medications.58,59

Concerns about specialty pharmacies

  • When health plans require that patients use specific specialty pharmacies, it limits their choice as consumers. Further, while some specialty pharmacies offer expert personalized service, a growing number of insurer-designated pharmacies operate entirely through the mail. Patients report difficulties refilling prescriptions, suffer long waits to reach customer service representatives and experience life-threatening shipment delays and dosage errors for critical drugs. Consumer Watchdog, a consumer advocacy group, has sued several insurance providers on behalf of patients taking HIV medications, alleging that restrictive specialty pharmacy requirements were discriminatory.

    When drug manufacturers limit which pharmacies carry their specialty products, patients and their clinicians may need to coordinate with multiple pharmacies to fill their prescriptions.58 Worse, they may discover that the drug best suited to a patient’s treatment is not carried by the pharmacies in their insurer’s network.60

    Critics question whether the tight network of specialty pharmacies, drug manufacturers, PBMs and insurers puts profits above patients. In 2020, the three largest PBMs—CVS Caremark, Express Scripts and OptumRx, all owned by health insurers—processed 85% of all prescription claims and handled drug benefits for more than 266 million Americans.7 Insurers can require patients to fill prescriptions at a pharmacy they run, while also setting patient copay rates and out-of-pocket caps. Some patient advocates worry this poses a conflict of interest that acts as a disincentive for insurers and PBMs to keep costs low for patients. 7,61

Specialty pharmacies fact sheet infographic

Common UM Practices & Consequences

Copay Accumulator Programs

Many patients use coupons and other forms of copayment assistance to manage prescription drug costs. Copay accumulator policies exclude the dollar amount of copay assistance from out-of-pocket totals, making it more difficult for patients to afford their medication while allowing health plans and pharmacy benefit managers to get paid twice.

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What are copay accumulator programs?

  • Copay accumulator programs, a recent addition to the insurance UM landscape, radically change the way patients with serious conditions pay for medications. Patients taking high-cost drugs often rely on drug manufacturer coupons or funds from charities like CancerCare to cover expenses their pharmacy benefits do not. Typically, the dollar amount of this copay support counts towards the patient’s annual out-of-pocket spending maximum and moves them closer to reaching their deductible. But under copay accumulator programs, insurers no longer count copay support toward a patient’s out-of-pocket maximum and deductible.

    This means it takes patients longer and costs them more to reach the point where insurance helps pay for covered drugs. And when copay support is no longer available, the patient must pay their copay in full until their deductible is finally met. This can be hundreds to thousands of dollars, even for a single prescribed medication.

    Ultimately, copay accumulator programs are “only adding more financial strain for patients who may be facing hardships due to the coronavirus pandemic’s impact on jobs and family budgets.”62

    Patients who receive copay support report being caught off-guard by the new accumulator policies. Consider this: for the first few months of the year, you fill your prescription for a drug that is in a high cost-share tier, contributing $20 toward each copay and using a manufacturer copay coupon to cover the rest. Then, when you pick up your prescription in April, you’re told you owe $3,000. You’ve used up the coupon, your deductible has not yet been met and you’re now solely responsible for the prescription’s full monthly cost-share amount. When that happens, you have three choices: scramble to cover the unexpected cost; contact your physician to find a lower-cost treatment, which may not be possible; or walk away without the medication.

    “Copay accumulator adjustment policies put patients with chronic conditions in a tough position—forcing them to choose between their health and other financial obligations.”62

    With more than one-third of commercially insured Americans in health plans that include a copay accumulator program of some form,63 you might wonder how such a pivotal policy change could catch people by surprise. One reason is that health plans don’t identify “copay accumulator programs” as such. Rather, insurers may refer to “coupon adjustment,” “variable copayment,” an “out-of-pocket maximum calculation process” or “pharmacy coupon adjustment changes”; others call it an “Out of Pocket Protection Program,” “Benefit Plan Protection Program” or “Copay Card True Program Accumulation.”63,64 There is no standard industry term used to help consumers quickly identify copay accumulator programs in action.

    In a survey by McKesson, 60% of patients believed copay accumulator programs were a benefit to them65; in reality, however, they benefit the health plan. The American Society of Clinical Oncologists agrees that the language used for copay accumulator programs is misleading: “While they are described as a benefit for patients, these programs in effect prevent patients from reaching their deductibles sooner. Copay accumulator programs generate large savings for employers and PBMs while increasing cost-sharing for patients.”66 Copay accumulator programs also provide insurers and PBMs with a financial boost, allowing them to “double dip” on deductibles. Even after the insurer collects the full deductible through a patient’s manufacturer coupons or other financial assistance, they still require the patient to pay the deductible in full (again) out of their own pocket.

Concerns about copay accumulators

  • Insurers and PBMs argue that manufacturer coupons for brand-name drugs undermine formulary design and increase spending by undercutting the cost savings offered by generic drugs. By requiring that patients pay more for brand-name drugs without using copay support—in a sense, putting more “skin in the game”—insurers and PBMs believe patients will seek out lower-priced drug options. This rationale, however, is flawed in several ways.

    First, the brand-name drugs that patients rely on may not have cheaper alternatives. One study found that the majority of brand-name drugs with copay coupons have no lower-cost generic equivalents.67 Many oncology drugs do not have substitutes that are both equally effective and less expensive for patients.

    Second, many patients delay or abandon treatment when faced with higher cost sharing, leading to expensive medical complications later. Numerous studies have found that higher out-of-pocket costs are associated with lower rates of filling prescriptions, delays in refilling prescriptions, higher rates of not taking medications as prescribed or abandoning them entirely.10 Patients who delay or abandon their drug treatment are at higher risk for expensive emergency care, avoidable hospitalizations and poorer health outcomes. Employers who choose health plans that use copay accumulators may see these costs reflected in increased illness-related absences and declines in productivity.

    In contrast, improving drug coverage and reducing patients’ out-of-pocket costs, including through the use of copay support, improves medication adherence and reduces the rate of expensive emergency care and hospitalization.68,69

    Adam J. Fein, CEO of Drug Channels Institute, summarizes the situation this way: “Higher utilization of specialty drugs is usually considered a positive trend. That’s because it’s well established that pharmaceutical spending reduces medical spending and improves patients’ health. Given the massive cost-shifting to patients, I expect that copay accumulators will reduce spending by decreasing the utilization of specialty drugs.”70 That is to say, short-term savings will come at the expense of patients’ long-term health and survival.

    “Given the massive cost-shifting to patients, I expect that copay accumulators will reduce spending by decreasing the utilization of specialty drugs.”


    - Adam J. Fein
    CEO of Drug Channels Institute

Meet the copay maximizer

  • To buffer the financial burden of copay accumulators, insurers have now started to adopt copay maximizer plans.71 Like an accumulator, a copay maximizer does not count copayment financial assistance toward the patient’s deductible and out-of-pocket maximum. The difference is that maximizer plans apply the value of the coupon or charitable support evenly throughout the benefit year, rather than using it up and then abruptly shifting all costs to the patient, as the accumulator does. Depending on the maximizer plan and type of copay support, some patients’ out-of-pocket costs may be eliminated or so low that they never reach their annual deductible or maximum. A patient might still pay more overall than they did with copay support, but much less than they would under a copay accumulator.

    While copay maximizer plans are more “patient friendly,” some come with restrictive requirements. Under maximizer plans, insurers and PBMs set the copay amount for drugs at the maximum value of the copay support, rather than basing it on the drug’s list price.71 So, a drug with a coupon that has a maximum annual value of $20,000 would cost a patient $20,000 annually to fill—regardless of their plan’s out-of-pocket maximums. To avoid that huge cost, patients have to enroll in the copay maximizer plan, which is handled by a separate business under contract with the insurer or PBM. These third-party businesses label high-cost specialty drugs as “non-essential health benefits,” a designation that removes the out-of-pocket limits required by the Affordable Care Act to protect patients.71 Confusing? Pharmaceutical industry watchdogs agree.

Are copay accumulators legal?

  • Although CancerCare, the American Medical Association, the American Society of Clinical Oncology and other leading medical organizations oppose copay accumulator programs, these plans received legal support from the U.S. Department of Health and Human Services and the Centers for Medicare and Medicaid Services (CMS) in 2021 policy determinations.

    Despite the CMS ruling, industry experts warn that copay accumulator programs may violate other federal laws that protect employees, patients and consumers, due to misrepresentation, lack of transparency, discriminatory practices, violations of patient privacy, and out-of-pocket maximums. Employers that choose health plans with copay accumulator programs may be putting themselves at greater risk for liability.

    The CMS ruling also leaves space for states to pass their own regulations on copay accumulator programs and, as policymakers recognize the harm of these practices, a growing number of states have moved to ban their use. As of July 2021, 11 states and Puerto Rico have enacted laws to restrict copay accumulator programs. Kentucky, for example, limits use by permitting accumulators only for drugs with generic alternatives, while granting doctors greater control to deem a brand-name drug medically necessary. However, state regulations do not extend to self-insured employer plans, so healthcare experts, physician groups and patient advocates strongly urge employers to reject or remove copay accumulators in their health plan design.

Case study: Copay accumulators, Jen & Penny Hepworth

  •      Jen & Penny Hepworth
         Salt Lake City, Utah
         Ankylosing spondylitis & cystic fibrosis
         Watch Jen tell her story »


    As a mother to two beautiful daughters and two wonderful stepsons, I want to provide a home filled with happy memories and vacations, but our medical costs have prevented us from doing so. Living with ankylosing spondylitis is not easy, and the combination of my disease and my daughter’s cystic fibrosis wreaks financial havoc on our lives.

    Ankylosing spondylitis is an autoimmune disease that affects my spine and all of my major joints. To stay healthy and avoid pain, I’ve been prescribed monthly immunosuppressants for years. On average, these cost about $10,000 per month. I also take daily pills prescribed by my doctor.

    In addition to my health challenges, my daughter was diagnosed with cystic fibrosis at three weeks old; she has two genetic mutations called DF508 and G551D. She was given a life expectancy of 41 years. As a parent, this is obviously something you never want to hear.

    Of course, we wanted to throw everything we had at this disease to give our baby girl the best life possible. The doctors put her on a medication called Kalydeco at two years old. This medication costs $300,000 annually. She’s now eight and recently switched to a CFTR modulator called Trikafta, which nets out at $311,000 a year.

    As an average American family living north of Salt Lake City, Utah, we do not have the finances to cover the overwhelming cost of these medications. Despite the fact that my husband is a very successful engineer, we’ve never had the chance to enjoy his financial gains due to the policies enforced by his employer’s insurance company. All I want is for our children to have positive family memories, but the monetary burden we carry from the insurance company continues to get in the way.

    The state of Utah allows insurance companies like ours to use a copay accumulator. Without any background, it sounds like a positive policy for the insured. We quickly found out that was not the case. This policy is used by PBMs/insurance companies to decrease costs for the insurer and increase costs for the insured. When manufacturers offer discounts or coupons on medications, the insurance company prevents those discounts from applying to patients’ deductibles and their maximum out-of-pocket spend. Since people end up paying much more than if the insurance company counted that support, the policy results in patients delaying or not seeking treatment.

    Our family has struggled under this policy. Without modulator drugs, a CF patient can expect annual hospital stays up to 14 days long and routine respiratory clean outs as the baseline—when symptoms present themselves, it only results in more doctors and more treatments. This all adds up. For our family, the only way we’ve been able to keep our daughter’s hospital visits to a minimum is to keep her on these expensive drugs. The only way we’ve been able to maintain access to these drugs is through financial aid from a multitude of sources. Between the two of us, we see rheumatologists, EMTs, a pulmonologist, a gastroenterologist, a social worker, a dietician and a respiratory therapist on a regular basis. Not to mention the daily pills and monthly injections that help us function. The financial burden of these treatments and the lack of support from our insurance company has us living paycheck-to-paycheck.

    We’re not the only ones to suffer under copay accumulators—many patients struggle to feed their families and have more severe situations than us. It’s a challenging situation that could easily be changed if the insurance companies supported their beneficiaries instead of lining their own pockets.

Copay accumulator fact sheet infographic

Common UM Practices & Consequences

The Appeals Process

When insurers deny coverage

  • At some point, nearly all cancer patients will find their insurance plan has denied coverage for a prescribed medical service (called a claim). It could be a test, treatment, scan, surgery, procedure, medication or other care. Patients then have to decide whether to appeal and petition their insurer to pay.

    Patients who appeal insurance denials actually win coverage an estimated 50-60% of the time.72 Yet a review of 40.4 million claims denied by insurance companies in 2019 found that patients appealed only 0.2%.73

Why are claims denied?

  • The majority of denials stem from administrative issues: mistakes in coding, missing forms, incomplete billing or patient info, duplicate or overlapping claims, and late submissions. Other denials are due to claims that don’t follow the insurance plan’s rules and limits: for instance, lack of proper pre-authorization or exclusion from coverage altogether.

    A small number of claims, though significant for cancer patients, are denied based on their perceived medical value as “unproven,” “experimental,” “investigational” or deemed “not medically necessary” for a patient’s condition. Yet, insurer assessment may not (intentionally, perhaps) be keeping pace with cancer care innovation and increasingly customized treatments. Proton therapy, for instance, is a newer alternative to traditional radiation therapy that limits damage to healthy tissue while targeting cancer cells. For some patients with brain tumors, it could be an optimal treatment. But many major insurers refuse to cover proton therapy. 74

    The U.S. Inspector General recently probed the efficacy and accuracy of denials in an audit of Medicare Part D insurers. In 2017, 35% of pre-authorization requests for medications were initially denied.

    Among the denied requests that patients appealed, insurers later approved a whopping 73%—“suggesting that many initial denials of coverage are inappropriate.”28

    Surprisingly, receiving pre-authorization for care is not a guarantee that an insurer will pay for it. A pre-approved claim may be rejected later: a “retrospective denial.” With pre-authorization requirements on the rise, so are cases of retrospective denials that leave patients with hefty surprise bills. These denials can happen when the insurer objects to how billing was handled, indicates the procedure was performed too long after approval was granted, or determines after further review that the care was not medically necessary.75

    Designing benefits with stronger coverage and fewer UM controls—that is, health plans that avoid restricted formularies, heavy pre-authorization requirements and step therapy protocols—helps to reduce the number of denials employees encounter.

What it takes to appeal: the added cost of time & stress

  • To tackle an appeal, a patient (or their loved ones) must be proactive, persistent, thorough and able to withstand the stress and uncertainty of the process, on top of the stress and uncertainty of their illness. Patients often need to relay information between their doctor and the insurer to coordinate numerous details; for example, making sure any related bills aren’t sent to a collection agency, which would hurt the patient’s credit rating.

    In the best case scenario, patients may be able to resolve administrative issues with an insurance representative over the phone—most likely after several lengthy calls—and resubmit the claim without going through a formal appeal. Other denials, particularly those regarding medical necessity, require a formal and often arduous written appeal and supporting evidence to make a strong case for coverage. It typically requires the healthcare team to gather documentation, which may include data from medical records and clinical studies, to back up the rationale for prescribed care. If a claim is still rejected after appealing, some plans allow for a second internal appeal, or a patient can file an external appeal with state-certified reviewers, independent from the insurer, who deliver a final decision.

    Patients waiting on appeal decisions find themselves in healthcare limbo. Do they continue with treatment, not knowing how much they may have to pay? Or do they delay care, not knowing how their condition may worsen? It can take 30 days for pre-authorization appeals to be adjudicated and 60 days for post-treatment appeals. In emergency or critically time-sensitive cases, patients can start an external appeal at the same time as their internal appeal to expedite a final decision in a matter of days. Clear timelines for decisions are crucial. Some employers now have clauses that automatically require insurers to cover a prescription if an appeal decision is not delivered by a set time.

    The Affordable Care Act (ACA), established in 2010, has helped lift some of the appeal-process burden from patients. Insurers in employer-sponsored health plans must disclose why a claim was denied. If a denied claim would stop or reduce a patient’s on-going care, ACA requires that insurers cover treatment until the appeal is settled. (If the patient ultimately loses the appeal, they would need to cover the cost of that care—which could be substantial.)

    Many physicians and healthcare advocacy groups argue that to reduce the need for appeals, the pre-authorization process and claim approvals should be more standardized and streamlined. Clinicians point to the “increasingly complicated criteria” and “unique contract requirements” that vary from health plan to health plan. As one healthcare professional put it, “It’s time, it’s energy, it’s effort. It’s relentless.”76

Appeals process fact sheet infographic

Common UM Practices & Consequences

Financial Non-adherence

High prescription copayments and other out-of-pocket fees can dangerously impact patients' use of medication. Financial non-adherence means that a patient may not follow their prescribed treatment plan because it is too costly. This includes cutting pills in half or abandoning their treatment altogether.

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What is financial non-adherence?

  • Cancer is expensive. When a patient learns they have cancer, the first concerns are about treatment and prognosis. As the patient begins treatment, however, they quickly wonder how much this will cost. A 2018 ASCO survey revealed that in the face of a cancer diagnosis, Americans would consider financial cost more worrisome than death.77 Direct out-of-pocket costs include deductibles, coinsurance and copayments for services covered by insurance, plus all costs for services that are not covered. For cancer patients and their families, that’s just the tip of the financial iceberg. The indirect costs of cancer include transportation to medical appointments, caregivers for the patient, child and/or elder care, pet care, special diets, cosmetic and over-the-counter items, mental health services, complementary therapies, lost work hours, disability and job loss.

    Nearly $4 Billion

    The amount patients paid in out-of-pocket costs of the $87.8 billion spent nationally on cancer-related healthcare in 2014.78

    $1,000-$10,000

    The annual range of individual out-of-pocket healthcare spending for the majority of cancer patients surveyed in 2019.

    20%

    The percentage of cancer patients that paid more than $20,000.14

    The high and on-going costs of cancer can lead to a state of financial toxicity, an umbrella term describing all the financial side effects patients and families suffer during treatment. Nearly 50% of cancer patients experience financial distress, which is associated with decreased health-related quality of life. In a review of bankruptcies, researchers found that 62% were due to medical debt, despite three-quarters of those in debt having health insurance. Another study found that cancer patients were nearly three times more likely to declare bankruptcy than people without cancer.79

    Financial stress can directly impact a patient’s survival. In a 2021 study, patients who reported “significant financial worry” at the start of treatment were “twice as likely to experience poor outcomes”; their risk of dying was roughly double that of otherwise similar patients.80 Researchers have also found that cancer patients who declare bankruptcy are nearly 80% more likely to die than patients who don’t, with even higher mortality rates for some cancers. Possible contributing factors range from increased stress to delayed, skipped or terminated treatments due to cost81—an all-too-common issue labeled financial non-adherence.

    A large, national study published by CancerCare in 2016 found that many patients, especially those aged 25 to 54 years, took steps to reduce their healthcare costs, some of which may have compromised their cancer treatment:

    • 39% skipped doctors’ appointments
    • 38% postponed or did not fill prescriptions
    • 34% skipped doses of prescribed drugs
    • 30% ordered medication from non-US sources
    • 31% cut pills in half82

    Financial non-adherence also impacts the management of chronic conditions. Non-adherence among patients with diabetes, for example, can lead to serious and costly complications, including nearly double the healthcare costs, higher hospitalization rates and an increased risk of death.83,84

    Patients with higher financial burdens are nearly twice as likely to delay taking or opt not to take prescribed medication.11

    One study found that prescriptions with $40-$50 copayments were 3-5x more likely to be abandoned at the pharmacy than prescriptions with no copayments.9

    Overall, financial nonadherence is associated with worse outcomes, disease progression, increased emergency care and higher hospitalization rates. Employers may see the effects in higher medical costs, as well as higher rates of absenteeism and presenteeism.

    Researchers note that “it is important to educate patients that saving some money today by non-adherence to treatment may mean spending much more money in the future.”84 This lesson is also true for employers: making care more accessible from the start improves outcomes by multiple measures, speeding recovery, improving productivity and reducing further medical costs for patients and the health plan. Experts agree that ensuring patients have access to affordable, adequate health insurance is the key to avoiding financial toxicity, and companies can improve outcomes starting with the choices they make about health plan design. Lower deductibles and reduced copays for medications improve adherence and outcomes, reduce costs in the long run and support employee retention, productivity and satisfaction.

Making out-of-pocket costs more manageable

  • To address financial non-adherence, employers can use alternative payment structures that make prescriptions costs more manageable for employees—instead of the budget-blowing shock of owing thousands of dollars in one pharmacy visit. One option is to create monthly caps for out-of-pocket spending, in addition to setting an annual maximum. Another option, commonly referred to as “smoothing,” allows employees to split large bills into smaller payments they can make over time. Many patients with cancer and chronic conditions face large out-of-pocket costs at the start of the plan year, before reaching their deductible and maximum; smoothing turns those major up-front costs into more manageable and predictable monthly payments. A smoothing option has been proposed as part of federal policy for Medicare drug plans.85 CancerCare, the Patient Access Network and other leading health advocacy groups call on “Congress, insurers, and other stakeholders [to] modify the structure of public and private insurance plans to spread out-of-pocket costs for prescription medications evenly over the course of the year so that patients can access and remain on the treatments they need.”86

    Employers can also include “copay only” prescription drug plans among the insurance options offered to employees. These plans guarantee fixed copays for prescription drugs at every formulary tier and avoid the use of coinsurance. With coinsurance, patients pay a percentage of a medication’s price, which means their out-of-pocket costs can vary significantly. Coinsurance is often calculated from a drug’s full, pre-rebate list price, so patients also end up paying more—especially those who rely on high-cost specialty drugs. Copay-only plans keep out-of-pocket costs lower and “provide more transparent and predictable cost sharing”87 that helps to ease the financial uncertainty of filling prescriptions. Copay-only design is now part of all standardized health plans offered through the Massachusetts insurance marketplace.88

Addressing High Deductible Health Plans

  • High Deductible Health Plans (HDHPs) have become increasingly common among employer-sponsored plans. As the name suggests, employees in a HDHP plan are required to pay a high deductible (at minimum $1,400 for individuals or $2,800 for families) before the plan starts contributing to their healthcare coverage. The upside is a lower monthly premium, which appeals to some employers and employees alike. While HDHPs may work well for people in good health with low healthcare costs, they can be inadequate for those with greater healthcare needs or lower incomes. In a 2019 survey by the Kaiser Family Foundation and the LA Times, two-thirds of the respondents in HDHPs did not feel confident they could cover the costs of a major illness for a family member with a chronic health condition.89

    Employers can help employees with HDHPs manage costs by pairing them with Health Savings Accounts (HSAs). HSAs allow enrollees to set aside tax-exempt money for medical expenses. Employers can also make pre-tax contributions to these accounts. HSAs are subject to very explicit IRS regulations and only specific types of HDHPs are qualified to be paired with an HSA.

    HDHPs with HSAs can also cover some preventive care benefits even before employees meet their deductible. In 2019, the IRS expanded the list of eligible pre-deductible services to include certain treatments for chronic conditions such as heart failure, heart disease, asthma or diabetes. There is evidence that covering these treatments and services with no cost sharing is beneficial to enrollees in many ways, showing lower rates of treatment non-adherence, improved patient health, and reduced financial costs to patients, which in turn can lower downstream healthcare costs. In the first year following the new IRS rules, 20% of employers with HDHPs waived some cost sharing for prescription drugs so that employees with chronic illnesses would be more likely to take their medications as prescribed. Among employers with 5,000 or more employees, nearly half expanded the services or products that individuals with chronic conditions could receive before meeting annual deductibles requirements.90

Case study: Financial non-adherence, Rita Anderson

  •      Rita Anderson
         Colchester, Connecticut
         Stage III breast cancer
         Watch Rita tell her story »


    I was diagnosed with Stage III breast cancer at the onset of the pandemic, in March 2020. I was 47 years old, divorced and was taking care of my youngest children and frail mother. Battling cancer quickly became my priority, but soon this was halted due to a lack of support from my insurance company.

    While the severity of my condition required immediate surgery, my operation had to be postponed because of the pandemic. So, I started with chemotherapy for the time being. Luckily, I was able to have the surgery six months later, but the medical team wasn’t able to remove all of the cancer. From there, I really started to worry about my future, as the cancer could still be growing and spreading. The oncologist had me start radiation every single day for two months, until I was prescribed my oral chemotherapy at the start of 2021. I had to take medical leave for the entire year and had to use my 401(k) to survive and support my family.

    Every year, my employer made us switch insurance companies, and the new company was extremely resistant to helping me through my cancer journey. I discovered this when I went to pick up my prescription: despite paying $670 per month for insurance, they quoted me $3,005 for my first month of oral chemotherapy. Like most patients, I did not have the funds for this, as it was my entire deductible. I spent hours on the phone with different associates at the insurance company, but they would not budge on the cost or even consider a payment plan to grant me access to a life-saving treatment. I asked my employer for help, since I worked at a pharmacy. I even sought assistance from a cancer patient fund, but no one could financially support me. My insurance company ultimately denied my claim. As a result, I couldn’t go on my medications as prescribed. This caused a panic—both for me and my oncologist.

    After two months without the chemotherapy drug, my oncologist had me try everything. Every doctor’s appointment I had started with, “How much is this going to cost? Will it go towards my deductible?” I attempted to get a prescription through my general practitioner, but there were complications. I called so many people, but it was just a waiting game at that point. It was beyond frightening. Finally, with urging from my oncologist, I reached out to drug manufacturers directly. This ended up being the route that worked, but it wasn’t without its challenges. The Xeloda drug finally came in April 2021.

    The most shocking part of the entire process was learning from my doctor that this kind of treatment delay due to cost was entirely normal for patients. The insurance companies have such a hold on patients through deductibles and other expenses, that they end up forcing patients to miss out on actively fighting their disease. Having had two months where I couldn’t do anything to fight the cancer in my body has been mentally challenging as well. It is so frustrating knowing that I could have been set up in a better situation for my health, but issues with my health insurance stopped me from doing so. This drug is lifesaving, and I want to do everything to be able to have a great life with my family. I’m still fighting to this day and doing my best, while also hoping for no additional insurance challenges.

Financial non-adherence fact sheet infographic

Resources for Employers

To help inform the benefits package design and decision-making process, here are key considerations when looking at plans that include utilization management. In this section of the toolkit, you’ll find best practice recommendations and questions that will help you evaluate health plan options based on these considerations.

Key Take-Aways for Benefit Design

Introduction

  • The evidence is very clear that common utilization management practices can negatively impact patients, particularly those with cancer and other serious conditions, in numerous ways:

    • Delaying, disrupting or denying necessary and time-sensitive care
    • Increasing out-of-pocket prescription costs, which can drive treatment non-adherence and result in long-term financial problems
    • Adding time-consuming administrative burdens for patients and healthcare providers
    • Creating barriers to receiving personalized care
    • Devaluing what matters to patients regarding their care and quality of life

    Because nearly two million Americans receive a new cancer diagnosis each year and many more manage chronic conditions, such as the roughly 34.2 million adults living with diabetes, it is critical that these areas of concern are addressed when designing a company’s health benefits package. Ultimately, a quality prescription coverage plan not only benefits patients, but employers, too: it can support productivity, help reduce long-term medical spending, attract and retain talented employees and build satisfaction and loyalty by demonstrating that the company values its staff.

Pre-authorization

  • Pre-authorization policies can cause delays in treatment or limit access. They can also be extremely time consuming for clinical staff. Both the American Society of Clinical Oncology and the American Medical Association have published recommendations to help payers limit the barriers to care created by PA.91,37 The highest priority is given to eliminating delays to care, with multiple recommendations to revise and streamline the burdensome processes currently in place.

Formulary Design

  • Many drug therapies used to treat cancer are placed on the highest or specialty tier of formularies, often requiring patients to pay higher out-of-pocket costs to access them. These drugs may provide the best treatment option for patients, and, in many cases, a comparable lower cost option does not exist.91

    To address this, some employers have eliminated cost-sharing for medications or supplies related to chronic illnesses; some have also made coverage available for these services and treatments before employees reach their deductibles, a change supported by new IRS designations for “preventive care.”90

    Formulary design should not be guided by value assessments that use quality-adjusted life years (QALYs), such as the ICER model, due to their discriminatory nature. Further, mid-year formulary changes should be avoided, as they disrupt care, can require patients to change medications even though there is no clinical reason (i.e. non-medical switching) and can also result in higher out-of-pocket costs.

Step Therapy

  • Step therapy not only delays care for patients with cancer, but can prevent those patients from accessing the best treatments available for their specific case and condition. Many leading medical organizations have called on insurers and PBMs to eliminate the use of step therapy.

Cost Sharing

  • Health insurance does not eliminate financial distress among cancer patients. More and more, costs are being shifted to patients, increasing the financial burden and putting them at risk of financial toxicity. It’s important to ask for clear and specific details on how cost-sharing is structured: for instance, copay accumulators and similar practices do not have industry-standard names.

Pharmacy Benefit Plan Recommendations

This section outlines practical steps employers may be able to take to address common utilization management practices and improve prescription benefit design for their employees.

Overview

  • The bottom line: Covered employees and other beneficiaries should be able to access their prescribed medications without delays, administrative barriers, interference with the physician/patient relationship or excessive financial burden. As long as there is sound clinical evidence supporting coverage, patients should have access to medications prescribed by their physicians.

    Health plans and pharmacy benefit managers should publicly disclose, in a searchable electronic format, patient-specific utilization management requirements per ACA guidelines, including:

    • Pre-authorization
    • Step therapy
    • Formulary restrictions
    • Process for formulary changes
    • Patient cost-sharing information, as applied to individual drugs and medical services
    • Restrictions and provisions around specialty pharmacy utilization and drugs
    • Measures to ensure rebates from manufacturers are passed on to patients

    Such information should be accurate, current and include an effective date in order to be relied upon by clinicians, patients and any prospective patients engaged in the enrollment process. Additionally, prescribing/ordering clinicians should receive clear information from health plans about what supporting documentation is needed to complete every pre-authorization and step therapy exception request, as well as appeals.37

I. Formulary Design

  • Policies to Avoid

    Don’t use “closed” formularies that limit access and exclude drugs. If you’re already working with a closed formulary, see our recommendations to improve its design.

    Avoid value assessments based on the Quality-Adjusted Life Year (QALY), such as those conducted by the Institute for Clinical and Economic Research (ICER). Don’t use these discriminatory metrics when designing a formulary or assigning drugs to tiers.

    Prevent mid-year changes to formularies. Frequent changes to formularies create obstacles for patients and physicians, leading to non-compliance, adverse reactions, increased costs and erosion of patients’ confidence. Changes to formularies should only be permitted at the start of a plan year with sufficient notice given to plan participants so they may use open enrollment periods to change to a plan with a more suitable formulary design. (This guideline is not meant to exclude newly FDA-approved drugs or indications.)92

    Don’t implement absolute “exclude at launch” policies for newly approved drugs. These drugs may represent breakthrough treatments or changes in standards of care, particularly important for people with cancer and rare conditions for which there may be few options.

    Don’t limit or exclude coverage for drugs that have stabilized a patient’s condition. This applies to a covered individual who: (a) is medically stable on a specific drug, as determined by the prescribing healthcare professional, and (b) has received coverage for that medication during the current plan year or a previous year.

    Take care not to create cost-sharing arrangements that disproportionately impact certain patients, such as those with cancer, by placing all or most medications for their illness on the highest cost-sharing tier.

    Recommendations

    Create an “open” formulary that allows all FDA-approved drugs to be covered when appropriate and medically necessary. Any formulary rules should be patient-centered and incorporate evidence-based standards of care.

    Focus on minimizing out-of-pocket costs for patients with chronic conditions to increase medication adherence and improve patient wellbeing. Consider offering a copay-only plan option for prescription medications.

    Provide coverage for off-label use of drugs and biologics when supported by evidence and expert consensus. Examples of off-label use of cancer drugs appears in the NCCN Guidelines® and NCCN Drugs & Biologics Compendium®.93 Off-label use of drugs is much more common in cancer treatment than in the treatment of other conditions. An estimated 50% or more of cancer care is off label—i.e. the drug or biologic has FDA approval, but not for use in that specific manner.

    Require expert reviewers for formulary exceptions and appeals. All plan or PBM decisions on exceptions or appeals must be made by a physician in the same or a similar general specialty as typically manages the medical condition or treatment under discussion. Too often these reviews are done by individuals who do not possess expertise in the clinical area.

    Require rebates to be passed on to patients. Patients should benefit from negotiated discounts such as rebates. Employers should require that all rebates or at least a designated percentage of rebates be passed on to patients to decrease their out-of-pocket costs.

    Guidelines for making formulary changes

    • Notify affected subscribers and beneficiaries of any formulary changes from year-to-year prior to the start of any open enrollment period or, if no open enrollment period exists, at least three months before the start of the new plan year.
    • Formulary changes notwithstanding, allow enrollees and their beneficiaries to continue with a previously approved drug until and unless a physician, in consultation with the patient, decides to change to another drug.

    Recommendations for improving “closed” formularies

    • Base the drug selection and formulary tiers primarily on clinical outcomes, clinical comparability, safety, patient ease of use and bioequivalence, with the PBM’s drug unit cost being a secondary consideration. Manufacturer rebates should not influence tier placement or preferred status.
    • Only restrict access to those classes of drugs most frequently abused, in order to provide access to as many classes of therapeutic agents as possible.
    • Ensure that medications to treat a specific disease state are not all placed in the highest tier.
    • Place generics on the lowest cost-sharing tier. If a drug does not have a generic equivalent or biosimilar, the brand-name drug should be placed on the lowest tier.
    • Ensure there is a transparent and timely process for prescribing and accessing drugs not included on the formulary. The process must use patient-centered, clinically based criteria and allow plan participants, their beneficiaries or prescribing physicians to easily request an exception.
    • Allow exceptions to formulary exclusions if they include any of the following justifications:
      • The treatment being requested is indicated based on genetic/genomic or other precision medicine tests for the individual’s diagnosis and the genetic profile of their illness.
      • Treatments available on the formulary have been ineffective in the treatment of the patient’s disease or condition.
      • The prescribing physician believes that delaying effective treatment would lead to severe or irreversible consequences and the treatments included on the formulary are likely to be ineffective given the patient’s physical or mental condition.
      • The prescribing physician believes that formulary treatments have caused or are likely to cause an adverse reaction or other physical harm to the patient, based on clinical, peer-reviewed evidence or the patient’s clinical history.
      • The prescribing physician believes that formulary treatments have prevented or are likely to prevent a patient from performing daily life activities or occupational responsibilities (see section 441.505 of title 42, Code of Federal Regulations or successor regulations).
      • The patient: (a) is stable on the prescription drug(s) selected by the prescribing clinician, and (b) has previously received approval of the drug(s) for their disease or condition by any group health plan or health insurance issuer.

    Time limits for the exception process

    • Non-emergencies - No later than 72 hours after receiving an initial exception request, the health plan must respond with either a determination of eligibility or a request for additional information (if strictly necessary to establish eligibility). After receiving additional information, the plan must respond with a decision no more than 72 hours later.
    • Emergencies - The plan has 24 hours to make a determination or request additional information. The plan must make a decision within 24 hours after the additional information is submitted.

II. Pre-authorization

  • Policies to Avoid

    Pre-authorization should not be required for first-line therapies, generics, drugs approved 90% of the time and drugs for which there are no alternatives to treat a certain disease.

    Don’t require new pre-authorizations for a patient who is stable on a particular drug. To ensure continuity of care, they should be exempt from any new pre-authorization requirements—such as when joining a plan or if the plan changes its formulary to require pre-authorization.

    Recommendations

    Waive pre-authorizations for trusted clinicians. If a prescribing clinician orders a particular medication at least five times in a six-month period and at least 90% of their orders pass pre-authorization review by any health plan, then the clinician should be exempt from needing pre-authorization for that medication for the next six months (or longer).

    Set up clear time limits so pre-authorizations are decided swiftly. If the plan fails to meet deadlines, pre-authorization should be automatically approved.

    Recommended Timelines for pre-authorization review

    • Non-emergency - No later than 72 hours after receiving a pre-authorization request, the health plan must respond with either a decision or a request for additional information. After receiving additional information, the plan must respond with a decision no more than 72 hours later.
    • Emergency - 24 hours. Emergency is defined as a reasonable medical probability that delay in the treatment could: (a) seriously jeopardize the patient’s life or overall health, (b) affect the patient’s ability to regain maximum function, or (c) subject patient to severe and intolerable pain or side effects.

III. Appeals Process

  • Recommendations

    Establish a clear, accessible, and timely processes to appeal denials. Information on the documents required and the specific criteria used to determine eligibility should be available in plan documents and on the plan’s website.

    Limit the information plans can request for appeals to what is strictly necessary to establish eligibility and/or medical necessity.

    Require expert reviewers for appeals. Reviews should be conducted by a physician in the same or a similar general specialty as typically manages the medical condition or treatment under discussion.

    Time limits for the appeals process

    • Non-emergencies - No later than 72 hours after receiving an initial appeal, the health plan must respond with either a determination of eligibility or a request for additional information (if strictly necessary to establish eligibility). After receiving additional information, the plan must respond with a decision no more than 72 hours later.
    • Emergencies - The plan has 24 hours to make a determination or request additional information. The plan must make a decision within 24 hours of the receipt of additional information.

IV. Step Therapy

  • Time limits for the appeals process

    Don’t include step therapy in your prescription coverage plans. Ideally, any step therapy protocols should be removed or excluded.

    Recommendations

    To address pre-existing step therapy requirements until they can be removed, mirror the proposed federal “Safe Step Act” (summarized below) to protect employees from the unintended consequences of step therapy. In addition, any patient required to go through a step therapy protocol should only have to try one unsuccessful treatment before receiving coverage of the physician recommended therapy.

    Safe Step Act (S.464) Requirements

    • Plans must establish a clear and accessible process to request an exception, including what information is needed on the required documents and the specific criteria used to determine eligibility.
    • Exceptions to medication step therapy protocol should be allowed if they include any of the following justifications:
      • A patient has already tried the medicine and it has failed before.
      • Delayed treatment will cause severe or irreversible consequences. The drug is reasonably expected to be ineffective, and a delay of effective treatment would lead to severe or irreversible consequences.
      • Required drug will cause harm to the patient. The treatment is contraindicated or has caused/is likely to cause an adverse reaction.
      • Required drug will prevent a patient from working or fulfilling Activities of Daily Life (ADLs): basic personal everyday activities such as eating, toileting, grooming, dressing, bathing and transferring (42 CFR § 441.505).
      • The patient is stable on the prescription drug selected by his or her provider, and that drug has been covered by their previous or current insurance plan.
    • Plans must limit the information they request to what is strictly necessary to establish eligibility for an exception.
    • Exception decisions must be made by a physician in the same or a similar general specialty as typically manages the medical condition or treatment under discussion.
    • Time limits for the exception process: 72 hours in all circumstances, and 24 hours if the patient’s life is at risk.

V. Specialty Pharmacy Programs

  • Policies to Avoid

    Don’t charge higher copays and coinsurance if a plan member chooses an in-network pharmacy other than the one operated by the PBM.

    Recommendations

    Allow plan members to choose the in-network pharmacy they want to use for their prescriptions.

    Provide information on cost-assistance programs that can assist patients with the cost of prescription drugs.

    Offer counseling to individuals who are prescribed oral oncology medications or self-injectables to reduce the prescription abandonment rate.

VI. Cost Sharing

  • Policies to Avoid

    Don’t allow plans to use copay accumulators or maximizers. Instead, the plan and its PBM should count any coupons or financial assistance made by a third party toward an enrollee’s coinsurance, copayment, deductible and out-of-pocket caps.

    Oral anticancer drugs should not be subject to higher cost sharing. Instead, any cost sharing for prescribed, patient-administered anticancer medications should be no less favorable than the cost sharing for anticancer medications that are intravenously administered or injected by a healthcare provider, per the Cancer Oral Parity Act of 2021.

    Recommendations

    Keep any out-of-pocket costs affordable with limits of no more than $100 per prescription fill and/or an aggregate cap of $200 out of pocket per month.

    Require that the differences in patients’ cost sharing obligations between formulary tiers be minimal.

    Have zero or minimal copays for prescriptions that treat chronic conditions to improve patients’ health and increase medication adherence. If offering High Deductible Health Plans (HDHPs), ensure that the plan allows eligible medications for chronic conditions to be covered pre-deductible, consistent with IRS Notice 2019-45.

    Offer employees the option of copay-only plans at every tier for prescription medications.

    If step therapy requires use of a lower-cost medication that is unsuccessful, cost sharing for the higher-cost medication should be at the lower out-of-pocket cost.

    Where available, biosimilars should be offered to patients at a lower out-of-pocket cost than the originator drug.

    Provide employees with the option to ‘smooth’ their out-of-pocket expenses early in the plan year when they are faced with an annual deductible. This allows employees to split large bills into smaller payments they can make over time.

VII. High Deductible Health Plans (HDHPs)

  • Policies to Avoid

    Do not offer High Deductible Health Plans (HDHPs) without pairing them with an account that allows enrollees to use tax-preferred funds to pay plan cost sharing and other out-of-pocket medical expenses. In 2020, the IRS defined HDHPs as any plan with at least a $1,400 individual deductible or a $2,800 family deductible.

    Recommendations

    If offering a High Deductible Health Plan, ensure it is an HSA-qualified HDHP and pair it with a Health Savings Account (HSA).

    When structuring a High Deductible Health Plan with a Health Savings Account, make use of the IRS’s preventive care designation to provide pre-deductible coverage for eligible medications related to chronic illnesses. The IRS’s expanded preventive care designation (IRS Notice 2019-45), which allows high-deductible health plans to cover some treatments for chronic conditions before enrollees meet their deductibles, includes such drugs as insulin to treat diabetes and statins used to treat heart disease. View the full list.

Request for Proposal (RFP) Questions to Ask

This section outlines questions to ask in your RFP to determine whether a particular plan or PBM can meet the best practices described in this document. The best practices should be provided to your consultant as part of the scope of work and to include in final plan terms.

Questions About Formulary Design

    1. Does your plan include an open formulary? (i.e. all FDA approved drugs are covered and available to employees) [Yes/No]
      1. If no, how many drugs per therapeutic class are included in the formulary?
      2. If no, what is the specific process you use to determine which drugs to include or exclude from the formulary?
      3. Do you have a process for exceptions? [Describe the process, the timeline for consideration, the criteria for exceptions, the qualifications of the decision makers—do you require healthcare expertise in the relevant therapeutic area?]
      4. Are all FDA-approved generics and biosimilars available on the formulary?
    2. How are formulary tiers set? [Describe the process and criteria]
      1. How are manufacturer rebates utilized in determining your formulary tiers?
      2. Are rebates passed on to patients? If so, what percentage?
      3. On what tier are generics placed?
      4. If no generic exists, where are brand-name drugs placed?
      5. Does the plan exclude newly approved FDA drugs for a period of time following approval?
      6. Do you utilize QALY-based value assessments by the Institute for Clinical and Economic Research (ICER) or other research organizations in determining formulary inclusion or tiers? If so, how are they used?
    3. Are changes made to formularies during the plan year? [Yes/No]
      1. If so, what factors are considered before such changes are made?
      2. How much notice is provided to covered plan members?
      3. Is notice given to doctors of plan members who are taking the drugs affected by formulary changes?
      4. Are exceptions made for those plan members who are stable on a drug slated to be removed or moved to another tier?
        1. If so, does that happen automatically or does the patient have to appeal a denial?
    4. When do you publish your formulary for the following plan year?
    5. How and when do you communicate changes to affected plan members and their physicians?
    6. Do you allow plan members to continue on a previously approved drug until and unless a physician, in consultation with the patient, decides to change to another drug?
    7. When making formulary changes, do you consider the total cost burden to the patient and physician, including unexpected adverse outcomes, staff time and resources, additional office visits and laboratory monitoring? [Yes/No]
      1. Describe your process and the factors considered in making formulary changes.
    8. Does the formulary allow off-label use of drugs and biologics? [Yes/No]
      (Note: Off-label use of drugs is much more common in cancer treatment than in the treatment of other conditions. An estimated 50% or more of cancer care is off label—i.e. the drug or biologic has FDA approval, but not for use in that specific manner.)
      1. If so, what are the requirements for such use to be covered?
      2. What is the process for considering off-label use including the timeline for initial consideration and the timeline for appeals?

Questions About Pre-authorization

    1. Do you require pre-authorization for:
      1. First-line therapies [Yes/No]
      2. Generics [Yes/No]
      3. Brand names where no generic version exists [Yes/No]
      4. Drugs for which pre-authorization is approved at least 90% of the time [Yes/No]
      5. Drugs for which there are no alternatives for a specific disease [Yes/No]
      6. Patients who are already stable on a drug, whether newly enrolled or existing plan members [Yes/No]
    2. Do you have a waiver program for trusted clinicians? (That is, a clinician who orders a particular medication at least five times in a six-month period and at least 90% of the orders receive pre-authorization by any health plan, is then exempt from needing pre-authorization for that medication for the next six months.) [Yes/No]
    3. Describe your process and timeline for making pre-authorization decisions.

Questions About Appeals

    1. Do you have a clear, accessible and timely process to appeal denials? [Describe the process, the information required and the specific criteria used to determine eligibility.]
    2. Where is this information made available?
    3. What is your timeline for reviewing appeals?
    4. Describe the qualifications of the plan’s employees or designees who make the determinations for pre-authorization and appeals?

Questions About Step Therapy

    1. Does the plan include step therapy requirements? [Yes/No]
      1. If so, for which drugs and biologics is step therapy required?
    2. Do you have an exceptions process for step therapy consistent with the protections included in “The Safe Step Act”? [Yes/No]
      1. Provide a detailed description of the process for requesting an exception, the criteria to qualify for an exception, the timeline for consideration and appeal, and the qualifications of those making the decisions.
    3. How do you make the exceptions policy available to plan members and their physicians?

Questions About Specialty Pharmacy Programs

    1. Can the plan member choose the pharmacy they want to use for their prescriptions? [Yes/No]
      1. If so, are the copays and coinsurance the same regardless of the pharmacy they choose?
    2. Does the specialty pharmacy program offer counseling to individuals who are prescribed oral oncology medications or self-injectables to reduce the prescription abandonment rate? [Yes/No]
    3. Does the specialty pharmacy program provide access to information on programs that can assist patients with the cost of prescription drugs? [Yes/No]

Questions About Cost Sharing

    1. Does your plan offer deductibles and out-of-pocket caps (both monthly and annual) that are consistent with the recommendations in our RFP document? [Yes/No]
    2. Do you have a process for 'smoothing' out-of-pocket payments for plan participants whose prescription expenses exceed monthly out-of-pocket caps? [Yes/No]
      1. If so, describe the process.
    3. Do you offer a copay-only option in every tiered plan? [Yes/No]
    4. Do you have a list of specific chronic conditions with a set copay for medications that treat those conditions? [Yes/No]
      1. If so, what conditions are on the list?
      2. If so, what is the copay for medications that treat those conditions?
    5. Does the plan count all copayments and coinsurance toward the deductible and out-of-pocket cap regardless of the source of the payment (coupon, copay assistance, etc.)? [Yes/No]
    6. Do you have a process to ensure that cost sharing for prescribed, patient-administered anticancer medications is no higher than the cost sharing for anticancer medications intravenously administered or injected by a healthcare provider? [Yes/No]

Questions About High Deductible Health Plans (HDHPs)

    1. If you are offering an HDHP, is it an HSA-qualified HDHP? [Yes/No]
    2. Is it paired with an HSA? [Yes/No]
    3. Does the plan offer pre-deductible coverage for eligible medications related to chronic illnesses (consistent with IRS Notice 2019-45)? [Yes/No]
      (Note: ​​The IRS’s expanded preventive care designation, which allows high deductible health plans to cover some treatments for chronic conditions before enrollees meet their deductibles, includes such drugs as insulin to treat diabetes and statins used to treat heart disease. View the full list.

Pre-Authorization

Pre-authorization requires that certain medical services, treatments or prescriptions be approved by insurers before a patient can receive them. This process is supposed to control health care costs but can cause serious unintended consequences while not really saving money.

Formulary Design

A formulary is a list of drugs approved by a health plan, typically arranged into tiers. Plans often limit or change access to drugs for financial reasons, which can cause serious unintended consequences for patients.

Step Therapy

Step therapy is a protocol that forces patients to try one or a series of drugs before being allowed the drug prescribed by their clinician. Patients can endure weeks or months of delay while taking less effective, or even harmful treatments, which can be devastating for people with cancer or other serious conditions.

Copay Accumulators

Many patients use coupons and other forms of copayment assistance to manage prescription drug costs. Copay accumulator policies exclude the dollar amount of copay assistance from out-of-pocket totals, making it more difficult for patients to afford their medication while allowing health plans and pharmacy benefit managers to get paid twice.

Financial Non-Adherence

High prescription copayments and other out-of-pocket fees can dangerously impact patients' use of medication. Financial non-adherence means that a patient may not follow their prescribed treatment plan because it is too costly. This includes cutting pills in half or abandoning their treatment altogether.

QALY-Based Value Assessments

QALY, which stands for "quality adjusted life year," is a controversial metric used to assess whether the cost of a treatment corresponds to the potential benefits to the patient, but its design discriminates against older people and those with chronic conditions.

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Glossary of Terms

Benefit design
Benefit design is the set of rules that structure a health insurance plan and determine how healthcare services can be accessed under coverage. This includes decisions about how individuals can gain access to services, providers, treatments and medications; which will be covered by the health plan; and what amount of cost-sharing individuals will need to cover as out-of-pocket expenses through deductibles, copayments or coinsurance.

Biologic drug / biologic
Biologic drugs or biologics are derived from living organisms and produced in living cells (i.e. yeast, bacterial, human tissue or plasma cells). A piece of DNA is inserted into a living cell so it can instruct the cell to produce a specific molecule, such as a protein. Those molecules are then isolated to become the biologic drug’s active ingredient. Contrast this with traditional medications, which are smaller molecules created from specific chemicals by using a synthesis process. Biologics help the body “manufacture” substances that boost the immune system’s response and, in the case of some cancer treatments, target cancer cells.

Biosimilar drug / biosimilar
A biosimilar drug, or biosimilar, is a medicine that is very close in structure and function to a biologic drug (see definition). Biosimilars are developed using a comparable, but not identical, biologic agent and are marketed at a lower cost than brand-name biologics. According to the FDA, they are “a biological product that is highly similar to and has no clinically meaningful differences from an existing FDA-approved reference product.”

Claim
A claim is a formal request for payment after services that an insured individual or their healthcare provider submits to the insurer. The insurer processes and reviews the claim for completeness, accuracy and coverage eligibility. If the claim is determined to be covered, the insurer pays their required portion. If the claim is denied, the patient is responsible for the cost and may choose to pay or file an appeal (i.e. request that the insurer reevaluate their decision and provide payment).

Closed formulary - see “Formulary”

Coinsurance
Coinsurance is a portion or percentage of a healthcare service cost that an insured individual is required to pay under their health plan. For example, if an individual's coinsurance for prescriptions is 20%, they pay 20% of a drug's cost and the insurance plan pays 80%, together covering 100% of costs. The higher the coinsurance rate, the higher an individual's out-of-pocket costs. An individual may be required to reach a deductible (a pre-set amount of out-of-pocket expenses) before the health plan covers their portion of coinsurance.

Copayment (also: copay)
A fixed amount ($20, for example) a plan enrollee pays for a covered prescription or healthcare service after paying their initial deductible. The health plan pays the remainder of the cost for that prescription or service (e.g. $100 prescription - $20 copay by enrollee = $80 paid by health plan). (See also “Deductible”)

Copay accumulator program
Copay accumulator programs exclude from an individual's out-of-pocket spending total any prescription copay costs covered by drug manufacturer coupons, non-profit organizations and other sources of outside support. Previously, the dollar amount covered by copay support was counted toward the individual's deductible and annual out-of-pocket spending maximum, helping them reach these totals sooner. There is no standard industry term for copay accumulator programs: other terms used by insurers include “coupon adjustment,” “variable co-payment,” “out-of-pocket maximum calculation process,” “pharmacy coupon adjustment changes,” “Out of Pocket Protection Program,” “Benefit Plan Protection Program” or “Copay Card True Program Accumulation.”

Similarly, a copay maximizer program does not count copayment financial assistance toward the patient’s deductible and out-of-pocket maximum. The difference is that maximizer plans apply the value of the coupon or charitable support evenly throughout the benefit year, rather than using it up and then abruptly shifting all costs to the patient, as the accumulator does. A patient might still pay more overall than they did with copay support, but much less than they would under a copay accumulator.

Copay accumulator example: an individual has a copay of $500 for a specialty drug and a deductible of $1000. Thanks to a coupon from the drug's manufacturer, the individual only pays $25 to fill a prescription and the coupon covers the other $475. Previously, the full $500 copay would be credited to the individual's out-of-pocket spending and they would be $500 away from reaching the deductible. Under a copay accumulator, only $25 is counted toward the individual's out-of-pocket spending and they are still $975 away from reaching the deductible; the health plan collects the $475 covered by the coupon, but does not count that amount toward the individual’s out-of-pocket spending.

Deductible
A deductible is the amount an insured individual pays each year for most eligible services or medications before the health plan begins to share in the cost of covered services. For example, if an individual has a $2,000 yearly deductible, they'll need to pay the first $2,000 of total eligible healthcare costs before the plan helps to pay. Deductibles for family coverage and individual health plan coverage are different. Some health plans include separate medical and prescription drug deductibles.

Financial non-adherence
Financial non-adherence is when patients do not follow their prescribed treatment plan due to the costs. Examples include a patient who doesn’t fill a prescription, who delays or stops getting refills for a medication, or who alters the prescribed dosage to stretch a prescription due to high out-of-pocket costs. Higher rates of financial non-adherence are associated with restrictive drug benefits and other UM practices that increase out-of-pocket costs. Because financial non-adherence disrupts treatment, it can lead to worse health outcomes and higher expenses later when more intensive or emergency care is needed.

Financial toxicity
Financial toxicity is an umbrella term describing all the financial side effects of treating cancer, including direct costs (i.e. out-of-pocket expenses related to medical services and prescription drugs) and indirect costs (e.g. transportation to appointments, child care, new dietary needs and/or healthy groceries, potential job loss, etc.). Benefit design that increases cost-sharing for individuals, such as higher deductibles, higher copay or coinsurance rates, can worsen financial toxicity.

First-line therapy / first-line treatment (also: induction therapy, primary therapy, primary treatment)
A first-line therapy is the first treatment given for a disease. It is often part of a standard sequence of treatments, such as surgery followed by chemotherapy and radiation. When not used as part of a sequence, it is the treatment that is expected to provide the best results with the fewest number of side effects for most patients.

Formulary
The formulary is a list of drugs approved for coverage by a health plan. Insurers and PBMs arrange formulary drugs into tiers based on their price and clinical value; patients typically pay a higher copay or coinsurance rate to access drugs in higher tiers. Along with brand-name drugs, formulary tiers also incorporate generics and biosimilars—lower-cost drugs that provide the same benefits as their brand-name counterparts. In an “open formulary,” the plan sponsor pays a portion of the cost for all drugs, whether or not they are included on the preferred list. In a “closed formulary,” the health plan will only cover drugs listed on the formulary. Insurers and PBMs control which drugs are included and excluded from the formulary, a process often influenced by cash-back rebates from drug manufacturers (see “Rebates”). In very restricted formularies, they may approve just one option per drug class. Non-formulary drugs are not covered and enrollees must pay the full price to access them, unless approved through a formulary exception process (an appeal submitted by a patient and their prescribing clinician).

Generic drug / generic
A generic drug is a medication created to be the same as an existing approved brand-name drug in dosage form, safety, strength, route of administration, quality and performance characteristics, but marketed at a lower price. The Hatch-Waxman Act was written into law in 1984 to promote price competition through generic drugs once a brand-name drug’s patent protection runs out. Generic medicines work the same as brand-name medicines; however, as with any drug, some patients may experience side effects or other issues with generics and better tolerate the brand-name version.

High Deductible Health Plan (HDHP)
Compared to standard health plans, enrollees in HDHPs must pay a higher deductible; in exchange, their monthly premiums are typically lower. For 2021-22, the IRS defines a HDHP as one having a deductible of at least $1,400 for an individual or $2,800 for a family. An HDHP’s total annual out-of-pocket expenses for in-network care (including deductibles, copayments and coinsurance) cannot exceed $7,000 for an individual or $14,000 for a family. While the lower premiums may be appealing, patients with serious illnesses and chronic conditions can be burdened with major out-of-pocket expenses before the plan covers any part of their healthcare costs. To buffer these expenses, HDHPs can be paired with a health savings account (HSA). Enrollees and their employers can make pre-tax contributions to the HSA that can be spent on out-of-pocket healthcare costs. (See also “Deductible”)

ICER
ICER is an acronym used for the Institute for Clinical and Economic Review, a private research organization; the same acronym is also used for the organization's value assessment framework, the Incremental Cost-Effectiveness Ratio. As an organization, ICER evaluates the clinical and economic value of prescription drugs, medical tests, devices and health system delivery innovations. ICER’s value assessment framework is used to compare treatment options by calculating costs vs. health benefits. ICER typically uses a pre-set "cost-effectiveness threshold": for example, a cost-to-benefit calculation of no more than $100,000 per year for a treatment. Some health plans and pharmaceutical benefit managers use these calculations to make coverage decisions. CancerCare and other leading medical organizations have criticized ICER’s practices, citing its reliance on the discriminatory QALY standard (see “QALY”), its “one-size-fits-all” frameworks, lack of transparency and failure to incorporate real-world perspectives from patients, caregivers and physicians.

Non-adherence - see “Financial non-adherence”

Non-medical switching
Non-medical switching is when changes are made to a patient’s approved treatment for any reason other than side effects, efficacy or adherence. Non-medical switching can occur when an insurer eliminates coverage for a prescribed medication or adds policies that increase out-of-pocket expenses for a prescribed medication, pushing patients to switch to an alternate treatment preferred by the insurer. Non-medical switching may also occur when insurers offer pharmacists or patients a financial incentive to switch to a preferred drug.

Open formulary - see “Formulary”

Out-of-pocket costs / Out-of-pocket maximum
Out-of-pocket costs are a patient’s expenses for services, treatments and prescriptions that aren't reimbursed by insurance. Out-of-pocket costs include deductibles, coinsurance and copayments for covered services, plus all healthcare costs that aren't covered. Some plans place a cap on how much a patient has to pay out of pocket each year. Once a patient reaches the out-of-pocket maximum, the insurer will pay 100% of all covered healthcare expenses for the rest of the plan year.

Payers
Payers is a broad term used in the healthcare industry to refer to any organization that pays for healthcare services and may also set service rates, collect payments and process claims. While payers typically refers to health plan insurers, Medicare, and Medicaid, it can also refer to self-insured employers who provide health plan coverage.

Personalized medicine
Personalized medicine is healthcare informed by and tailored to a patient’s unique genetics and circumstances. An individual's genetics and background can be used to guide decisions about testing, prevention, diagnosis and treatment. In cancer care, precision or targeted treatments use a cancer's genetic profile to match it with a specific drug for improved outcomes.

Pharmacy benefit managers (PBMs)
Pharmacy benefit managers (PBMs) manage prescription drug benefits on behalf of many health plans and self-insured employers. PBMs aim to control drug spending across several channels and through a variety of utilization management tools: 1) they create the list of drugs covered by a health plan and determine how much patients must pay to access preferred vs. non-preferred drugs (see “Formulary”); 2) they negotiate directly with drug manufacturers on pricing (see “Rebates”); and 3) they manage relationships with pharmacies to further coordinate patients’ access to drugs and what they pay (see “Specialty pharmacy”).

Pre-authorization (also: prior authorization, prior approval, precertification, PA)
Pre-authorization is a UM policy that requires certain services, treatments or prescriptions be submitted to the insurer for review and deemed medically necessary before a patient can receive that care. An insurer may deny coverage if pre-authorization is not properly secured; granting pre-authorization, however, does not guarantee an insurer will pay for treatment. Securing pre-authorization is often a time-consuming process for patients and healthcare providers alike and can lead to delays in treatment.

Premium
A premium is a set fee paid for health insurance every month. The premium is paid separately from other expenses a patient may have for healthcare services and prescriptions, such as deductibles, copayments and coinsurance. Employers often cover a portion of the premium and employees cover the rest.

Presenteeism
An employee is physically present in the workplace, but their productivity is reduced due to feeling unwell and/or disruptions, such as lengthy calls with their insurer to appeal a coverage denial. Employees who are caregivers for ill family members may experience presenteeism as well.

QALY
QALY stands for “Quality-Adjusted Life Year” and is an older economic tool used to quantify the value of a treatment by determining how its cost corresponds to the potential benefit. The QALY model assigns comparative values to different treatments based on how long it would prolong life and how much it would improve quality of life, essentially creating a formula of “quality of life x quantity of life.” The QALY has drawn criticism and prohibitions under several federal statutes due to its narrow definition of “perfect health” that devalues and discriminates against people based on age, disabilities and chronic conditions, and fails to acknowledge diversity among patients and their different treatment needs and goals.

Rebate
Rebates are cash-back refunds paid to the pharmacy benefit manager (see “Pharmacy benefit managers”) by the drug manufacturer after a drug is sold—this way, the PBM’s final net price for the drug ends up being lower than the original list price. PBMs pass the rebates on to health plans; however, their contracts often allow them to keep a portion. High-volume rebates are a major source of revenue for many PBMs. PBMs negotiate rebates with drug manufacturers in exchange for a preferred lower-tier spot for a drug on their formulary, which offers wider use by patients.

Specialty pharmacy
Specialty pharmacies focus on medications for complex, chronic or rare medical conditions, including cancer. These drugs may require extra care to safely handle and dispense, or on-going patient monitoring. For cancer patients, specialty pharmacies can help coordinate the shipment of chemotherapeutics and the logistics of how they’ll be administered. A health plan may require that insured individuals use a specific specialty pharmacy. Some specialty pharmacies are now controlled by insurers and pharmacy benefit managers (see “Pharmacy benefit managers”), which has raised concerns about a conflict of interest when it comes to managing patients' out-of-pocket costs.

Step therapy
Step therapy, otherwise known as a “fail-first” protocol, requires patients to try one or more treatments from their health plan’s formulary (i.e. list of approved drugs; see “Formulary”) and demonstrate it fails to improve their condition before the insurer will cover a doctor-prescribed course of treatment. Often, patients are first required to use treatments that come at a cost-savings to the insurer before being approved for higher-cost prescriptions or, in some cases, prescriptions not included in the formulary.

Utilization management
Utilization management (UM) is an umbrella term for cost-containment techniques used to evaluate healthcare services and determine whether they are medically necessary and appropriate for patients—and ultimately, whether a health insurance provider should pay for them. UM sets the rules by which insurers restrict or deny coverage for care. At its best, UM helps to catch issues, weeds out unproven treatments, balances physicians’ decisions and reduces costs while delivering quality care. At its worst, UM creates administrative snarls and costly out-of-pocket expenses for patients and can stand between patients and their physicians when setting the best personal course of treatment.


Works Cited

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Acknowledgements

The Employers’ Prescription for Employee Protection Toolkit: Best Practices for Prescription Drug Benefit Design would not have been possible without the support and input of many organizations and individuals.

CancerCare Project Directors
Carole Florman
Ellen Miller-Sonet

Advisory Board
Susan Hensley, Pfizer
Jared Lewis, Curtiss-Wright Corporation; Board of Directors, Northeast Business Group on Health
Len Lichtenfeld, MD, MACP, CancerCare Board of Trustees
Joanna Morales, Esq., Triage Cancer
Jonathan Parker
Wayne Sichel, RPh, JD, Precision Value & Health; CancerCare Board of Trustees
Lynn Zonakis

Thank you for sharing your stories: Rita Anderson, Heidi Barrett, Chris and Michelle Bushell, Tony Coelho, Patricia Goldsmith, Jen Hepworth, Justin Williams, Amy W.

Thank you for sharing your wisdom: Christie Beausoleil, Eastern CT Hematology & Oncology; Jalpa A. Doshi, PhD, University of Pennsylvania; Anna Hyde, Arthritis Foundation; Dorothy Leone-Glasser, Advocates for Responsible Care (ARxC); Mark Peters, PharmD, CancerCare; Candice Sherman, Northeast Business Group on Health; Sara van Geertruyden, Partnership to Improve Patient Care (PIPC); Kimberley Westrich, National Pharmaceutical Council; Stacey Worthy, Aimed Alliance.

Thank you for sharing your talent: Chris Martin, Lever.Media; Bailey Bosworth, Adreanna Ditton, Loriana Hernandez-Aldama, Lindsay Huck, Joseph Lecz, Portia Marchman, David Parsons, Libby Pokel-Hung, John Onorato, Lisa Taylor.

The project was made possible with the generous support of Bristol Myers Squibb, Eli Lilly & Company, Janssen, Merck, Pfizer, Takeda.

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