In the United States, over 140,000 people are diagnosed with colorectal cancer every year.

Regular screening is one of the most powerful weapons for preventing colorectal cancer. The preferred test is a colonoscopy, in which a doctor uses a thin flexible tube equipped with a camera to look for polyps—small growths—on the wall of the colon. If undiscovered and untreated, polyps can become cancerous.

Treatment for colorectal cancer often involves a combination of surgery and medication.

Surgery

In approximately 80 percent of patients diagnosed with colorectal cancer, the cancer is localized (has not spread to other organs). Surgery is most often the first step in treating localized colorectal cancer. The surgeon will remove the section of the colon or rectum that contains the tumor and will also remove nearby lymph nodes, which are small organs located throughout the body that remove waste and fluids and help fight infection. Removing the colon or rectal tumor and nearby lymph nodes enables a pathologist (a physician who examines laboratory samples of body tissue for diagnostic purposes) to more accurately determine the stage of the cancer.

Chemotherapy

Chemotherapy is sometimes given before surgery to try to shrink the tumor (called “neoadjuvant” treatment), making the surgery an easier process and increasing its chances of success. Neoadjuvant chemotherapy is sometimes given in combination with radiation.

After surgery, cancer cells that are not detectable by tests may still exist, so doctors often suggest “adjuvant” treatment (chemotherapy given after surgery). The goal is to destroy any remaining tumor cells, decrease the chances of the cancer coming back and reduce the risk of tumor cells spreading to other parts of the body.

The chemotherapies most often given in adjuvant treatment are:

  • 5-Fluorouracil (Adrucil),), also called 5-FU, is given intravenously (through a needle into a vein), often with the vitamin-like drug leucovorin (folinic acid) which helps it work more effectively.
  • Capecitabine (Xeloda and others), taken in pill form, is changed by the body to 5-FU when it reaches the site of the tumor.
  • Oxaliplatin (Eloxatin) is given intravenously in combination with 5-FU or capecitabine.

If the colorectal cancer has spread to other areas of the body, such as the liver or lungs, doctors often treat the tumor with chemotherapy alone. In addition to 5-FU and capecitabine, metastatic colorectal cancer can be treated with the intravenous drugs oxaliplatin (Eloxatin) and irinotecan (Camptosar).

In 2015, the FDA approved Lonsurf (a pill that combines two drugs, trifluridine and tipiracil) for people with advanced colorectal cancer which is no longer responding to other therapies.

Targeted Treatments

Targeted therapies focus on specific molecules and cell mechanisms thought to be important for cancer cell survival and growth, taking advantage of what researchers have learned in recent years about how cancer cells grow. Targeted therapies are meant to spare healthy tissues and provide treatment against cancer cells that is more focused than chemotherapy.

  • VEGF inhibitors. These treatments “starve” the tumor by blocking the action of VEGF (vascular endothelial growth factor), a protein released by tumors that contributes to blood vessel growth (angiogenesis). VEGF inhibitors bevacizumab (Avastin), ramucirumab (Cyramza) and ziv-aflibercept (Zaltrap) are given intravenously, typically along with chemotherapy such as oxaliplatin, irinotecan, 5-FU and capecitabine. VEGF inhibitors can help make chemotherapy drugs more effective.
  • EGFR inhibitors. EGFR (epidermal growth factor receptor) is a protein often found in high amounts on the surface of cancer cells. The targeted therapies cetuximab (Erbitux) and panitumumab (Vectibix), given intravenously, are designed to block the action of EGFR, preventing cancer cells from growing into tumors. For patients with RAS wild-type tumors, they are often given in combination with chemotherapy.
  • Kinase inhibitor. Kinase proteins send important signals to the cell’s control center, including signals that promote cell growth. The kinase inhibitor regorafenib (Stivarga), taken in pill form, is designed to help stop the growth of tumors by blocking several kinase proteins.
  • TRK inhibitor. In November 2018, the FDA approved the TRK inhibitor larotrectinib (Vitrakvi) for the treatment of people with solid tumors (including colorectal cancer tumors) that have an NTRK gene fusion and have progressed following treatment or have no other satisfactory treatment alternative. Larotrectinib is “agnostic” in that it targets a genetic driver of cancer rather than a specific type of tumor.

Immunotherapy

Our immune system works constantly to keep us healthy. It recognizes and fights against danger, such as infections, viruses and growing cancer cells. In general terms, immunotherapy uses our own immune system as a treatment against cancer.

In 2017, the immunotherapy drugs pembrolizumab (Keytruda) and nivolumab (Opdivo), known as PD-1 inhibitors, were granted accelerated approval by the FDA for people with metastatic colorectal cancer that has progressed after chemotherapy and that has one of two specific genetic features (MSI-H or DNA mismatch repair deficiency), both of which can prevent DNA within cells from repairing itself.

In July 2018, the FDA approved nivolumab in combination with the immunotherapy ipilimumab (Yervoy) for the treatment of people with previously-treated metastatic colorectal cancer that is positive for either MSI-H or DNA mismatch repair deficiency.

Immunotherapy continues to be a key area of research in the treatment of metastatic colorectal cancer, including:

  • Vaccines.Vaccines that boost the immune system have the potential to treat colorectal cancer or prevent it from recurring after treatment. A number of vaccines are being studied in clinical trials. One vaccine approach involves removing a person’s own immune system cells from their blood, altering them with a substance that will instruct them to attack cancer cells and injecting them back into the person’s body.
  • Immune checkpoint inhibitors. Tumor cells often have “immune checkpoint” molecules that act as a shield, allowing the cancer to evade an attack by the immune system. This can be countered by immune checkpoint inhibitors, which are drugs designed to remove the shield and allow the immune system to attack the cancer cells.
  • Combining immunotherapy and targeted therapy. PD-1 is a molecular “brake” that prevents the body’s immune system from attacking tumors. Combining PD-1 inhibitors with targeted or other therapies that activate immune cells may stimulate the immune system to attack cancer cells.

All cancer treatments can cause side effects. It’s important that you report any side effects that you experience to your health care team so they can help you manage them. Report them right away—don’t wait for your next appointment. Doing so will improve your quality of life and allow you to maintain your treatment plan. It’s important to remember that not all patients experience all side effects, and patients may experience side effects not listed here.

Side Effects of Chemotherapy

The side effects of chemotherapy depend on the type and dose of drugs given and the length of time they are used, and can include:

  • Fatigue
  • Nausea or vomiting
  • Hair loss
  • Increased risk of infection (from having too few white blood cells)
  • Easy bruising or bleeding
  • Changes in memory or thinking
  • Peripheral neuropathy (numbness or tingling in hands and feet)

Chemotherapy can cause changes in the way food and liquids taste, including causing an unpleasant metallic taste in the mouth. Many people find that switching to plastic utensils helps. It may also help to avoid eating or drinking anything that comes in a can, and to use enamel-coated pots and pans for food preparation.

Side Effects of Targeted Therapy

Targeted therapy doesn’t have the same effect on the body as do chemotherapy drugs, but they can still cause side effects. Side effects of targeted therapies can include diarrhea, liver problems (such as hepatitis and elevated liver enzymes), nerve damage, rash, high blood pressure and problems with blood clotting and wound healing.

Side Effects of Immunotherapy

Immunotherapy travels through the bloodstream, helping to prompt an immune response. Because it can trigger an attack on healthy cells as well as cancer cells, certain side effects may be experienced, including fatigue, decreased appetite, and digestive tract symptoms. The management of these potential side effects is discussed later in the next section of this booklet.

General Side Effects

There are certain side effects that may occur across different treatment approaches. The following tips and guidance may help you manage these side effects.

Digestive Tract Symptoms

Nausea and vomiting

  • Avoid food with strong odors, as well as overly sweet, greasy, fried, or highly seasoned food.
  • Nibble on dry crackers or toast. These bland foods are easy on the stomach.
  • Having something in your stomach when you take medication may help ease nausea.

Diarrhea

  • Drink plenty of water. Ask your doctor about using drinks such as Gatorade which provide electrolytes as well as liquid. Electrolytes are body salts that must stay in balance for cells to work properly.
  • Over-the-counter medicines such as loperamide (Imodium A-D and others) and prescription drugs are available for diarrhea but should be used only if necessary. If the diarrhea is bad enough that you need medicine, discuss it with your doctor or nurse.
  • Choose foods that contain soluble fiber—for example beans, oat cereals, oranges, and flaxseeds. High-pectin foods such as peaches, apples, oranges, grapefruit, bananas, and apricots can also help to avoid diarrhea.

Loss of appetite

  • To help maintain your weight, eat small meals throughout the day. That’s an easy way to take in more protein and calories. Try to include protein in every meal.
  • To keep from feeling full early, avoid liquids with meals or take only small sips (unless you need liquids to help swallow). Drink most of your liquids between meals.
  • Keep high-calorie, high-protein snacks on hand such as hard-boiled eggs, peanut butter, cheese, ice cream, granola bars, liquid nutritional supplements, puddings, nuts, canned tuna, or trail mix.
  • If you are struggling to maintain your appetite, talk to your health care team about whether appetite-building medication could be right for you.

Managing Fatigue

Fatigue (extreme tiredness not helped by sleep) is one of the most common side effects of many cancer treatments. If you are taking a medication, your doctor may lower the dose of the drug, as long as it does not make the treatment less effective. If you are experiencing fatigue, talk to your doctor about whether taking a smaller dose is right for you.

There are a number of other tips for reducing fatigue:

  • Take several short naps or breaks.
  • Take short walks or do some light exercise, if possible.
  • Try easier or shorter versions of the activities you enjoy.
  • Ask your family or friends to help you with tasks you find difficult or tiring.
  • Save your energy for things you find most important.

There are also prescription medications that may help. Your health care team can provide guidance on whether medication is the right approach for your individual circumstances.

Fatigue can be a symptom of other illnesses, such as anemia, diabetes, thyroid problems, heart disease, rheumatoid arthritis or depression. Be sure to ask your doctor if he or she thinks any or these conditions may be contributing to your fatigue.

Managing Pain

To help your doctor prescribe the best medication, it’s useful to give an accurate report of your pain. Keep a journal that includes information on:

There are a number of options for pain relief, including prescription and over-the-counter medications. It’s important to talk to a member of your health care team before taking any overthe counter medication, to determine if they are safe and will not interfere with your treatments.

Physical therapy, acupuncture and massage may also be of help in managing your pain. Other techniques, such as mindfulness meditation, deep breathing exercises and yoga may also be helpful. Consult with a member of your health care team before beginning any of these activities.

As you manage your cancer, it’s important to remember that you are a consumer of health care. The best way to make decisions about health care is to educate yourself about your diagnosis and get to know the members of your health care team, including doctors, nurses, dietitians, social workers and patient navigators.

Here are some tips for improving communication with your health care team:

Start a health care journal. Having a health care journal or notebook will allow you to keep all of your health information in one place. You may want to write down the names and contact information of the members of your health care team, as well as any questions for your doctor. Keep a diary of your daily experiences with symptoms related to your illness or treatment. You can separate your journal or notebook into different sections to help keep it organized.

Prepare a list of questions. Before your next medical appointment, write down your questions and concerns. Because your doctor may have limited time, you should ask your most important questions first, and be as specific and brief as possible.

Bring someone with you to your appointments. Even if you have a journal and a prepared list of questions or concerns, it’s always helpful to have support when you go to your appointments. The person who accompanies you can serve as a second set of ears. He or she may also think of questions to ask your doctor or remember details about your symptoms or treatment that you may have forgotten.

Write down your doctor’s answers. Taking notes will help you remember your doctor’s responses, advice, and instructions. If you cannot write down the answers, ask the person who accompanies you to do that for you. If you have a mobile device, ask if you can use it to take notes. Writing notes will help you review the information later.

Remember, there is no such thing as over-communication.

Frequently Asked Questions

Q. I have been diagnosed with colorectal cancer, and I’m concerned about my children’s risk of getting the disease. What screenings or tests are recommended for them?

A. Typically, it is recommended that children undergo their first colonoscopy when they are ten years younger than their parent was at the time of their colorectal cancer diagnosis. It is also important to know whether you have an inherited condition, such as Lynch syndrome, which increases the risk of colorectal cancer. If your colorectal cancer is possibly inherited, your children should talk to their physician about genetic screening, in addition to undergoing colonoscopies at the recommended intervals.

Q. I was recently diagnosed with colon cancer and will soon have surgery. Will I definitely need to have a colostomy as part of the surgical process?

A. A colostomy is a procedure which diverts a portion of the colon to a small opening—called a stoma— in the wall of the abdomen. The stoma is attached to a pouch, which collects stools as they exit the body. Depending on the extent of your surgery, the need for a colostomy is possible, or even likely. However, there are options that may be available to you, which you should discuss with your surgeon or another member of your health care team.

If you do require a colostomy, there is support available to help you adjust to the change in your daily routine. It can be very valuable to speak with an oncology social worker at CancerCare; consulting with an enterostomal therapy nurse (who specializes in ostomy care and rehabilitation), and joining a local support group can also be very helpful . You can also read CancerCare’s fact sheet titled, “Colostomy: Finding Resources and Support” for more information.

Q. I heard about there being differences between left-side tumors and right-side tumors. What does that mean?

A. The results of the phase II clinical trial HERACLES-A showed that the combination of two HER2-targeted therapies, trastuzumab (Herceptin) and lapatinib (Tykerb), had clinical benefit in people with HER2-positive metastatic colorectal cancer whose cancer had not responded to other treatments. This is an encouraging development, as people with this type of colorectal cancer often do not respond well to available targeted therapies.

Q. Can following a ketogenic diet reduce the risk of colorectal cancer?

A. There are biological differences in tumors depending on their location within the colon. Metastatic colorectal cancer tumors originating from the left side of the colon (the descending colon, sigmoid colon and rectum) are associated with better outcomes than tumors originating from the right side of the colon (the cecum and ascending colon). These differences may help guide treatment approaches for people with metastatic colorectal cancer and will likely be the subject of increased focus in the coming years as researchers seek to more deeply understand the difference in treatment options and outcomes based on the location of the tumor.

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This booklet was made possible Bristol-Myers Squibb, Pfizer and Taiho Oncology Inc.

Last updated May 12, 2019

The information presented in this publication is provided for your general information only. It is not intended as medical advice and should not be relied upon as a substitute for consultations with qualified health professionals who are aware of your specific situation. We encourage you to take information and questions back to your individual health care provider as a way of creating a dialogue and partnership about your cancer and your treatment.

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