As treatments improve, men and women with liver cancer are living longer and with a better quality of life.

Liver cancer affects nearly 29,000 people in the United States each year. The major type of liver tumor is hepatocellular carcinoma, a cancer that forms in the main cells of the liver, called hepatocytes. If these cells are stressed by alcohol or the hepatitis B or C virus, they are at increased risk for cancer. Hepatocellular carcinoma accounts for about 90 percent of all liver cancers.

Hepatocellular carcinoma is a primary tumor––that is, it begins in the liver. This organ is a common site of metastatic tumors––tumors that have spread from a cancer in another part of the body. Almost any type of cancer can spread to the liver, including breast cancer, colorectal cancer, lung cancer and melanoma.

Before deciding how to treat your liver cancer, your team of experts will go over all the information it has gathered about your health. One of the most important factors in determining the best treatment (or combination of treatments) for you is the current status of your liver.

The factors your team will consider are:
• Whether there are tumors in more than one section of the liver;
• Whether the cancer has spread beyond the liver to other parts of the body;
• Whether blood vessels are involved;
• How much the liver has been damaged by the cancer;
• How much, if any, underlying damage is present, such as cirrhosis (a long-term disease in which liver cells are replaced by scar tissue).

Surgery

Standard surgery, or hepatectomy, is the surgical removal of the part of the liver affected by cancer. This procedure can only be performed in people who do not have severe liver damage and whose cancer has not spread to the blood vessels of the liver or other parts of the body.

Liver transplants are done most often in people whose tumors are very small, few in number, do not involve blood vessels and have not spread outside the liver. These tumors usually cannot be removed by surgery because of advanced cirrhosis. To receive a transplant, a suitable donor with a healthy liver must be found.

Treating the Liver Directly

Embolization or chemoembolization may be used as options to treat liver tumors that cannot be removed by surgery. In these cases, doctors may use a procedure called transarterial embolization (TAE, without chemotherapy) or transarterial chemoembolization (TACE, with chemotherapy). In these procedures, a catheter (a small plastic tube) is placed into the liver’s artery. An inactive substance, with or without chemotherapy, is injected directly into the liver tumor to control and kill the cancer cells. Although TAE and TACE may not destroy all the cancer cells, they can slow the growth of the tumor and perhaps stop it from growing.

Radiofrequency ablation (RFA) kills cancer cells with heat. An imaging technique such as ultrasound or CT scan is used to help guide a needle into the liver tumor. High-frequency electrical currents are then passed through the needle, creating heat, which destroys the cancer cells.

Cryoablation is similar to RFA, but this technique uses cold instead of heat to freeze tumors and kill them.

Radiation is sometimes used when a liver cancer cannot be removed by surgery. Although radiation kills liver cancer cells, very high doses can damage healthy liver tissue as well. So now, doctors use devices that deliver radiation beams more directly to the tumor, helping to spare healthy tissue.

Intensity-modulated radiation therapy (IMRT) is a technique that uses advanced computer technologies to map and plan a precise dose of radiation to the liver. The dose is based on the tumor’s size, shape and location. IMRT modulates, or controls, very thin beams of radiation at different intensities and angles. This allows the radiation beams to conform to, or fit, the three-dimensional shape of the tumor for a custom-tailored dose.

Radioembolization is a technique used by the radiation specialist to inject small radioactive beads into the main artery of the liver. This allows concentrated amounts of radiation to attack the tumor. Radioembolization delivers an intense dose of radiation to the cancer cells with less damage to healthy tissue. Patients remain awake during this procedure, which is usually performed in a hospital’s radiology suite.

Treating the Liver Systemically

Medicines given systemically go through the bloodstream to reach cancer cells throughout the body. These medicines include chemotherapy and targeted treatments. They are given when tumors have spread beyond the liver and surgery is not an option. In treating liver cancer, chemotherapy is not used as commonly as targeted treatments. Targeted treatments are more likely than chemotherapy to spare healthy tissues, but they may still cause side effects.

Sorafenib (Nexavar) has been approved by the U.S. Food and Drug Administration (FDA) for treating hepatocellular carcinoma since 2007. It works by blocking the action of proteins that promote the growth of new blood vessels. These blood vessels carry oxygen, minerals and other nutrients that tumors need to grow. Sorafenib also blocks a protein called RAF kinase, which helps signal cancer cells to grow and multiply. So far, sorafenib is the standard of care for liver cancer.

But clinical trials continue to search for ways to treat liver cancer that does not respond, or no longer responds, to sorafenib. Ongoing studies are combining sorafenib with a number of different treatments, including doxorubicin, a standard chemotherapy.

As you are being treated for liver cancer, it’s important that you let your health care team know about any side effects you experience. The more detailed and precise you can be, the more it will help your team treat you quickly and effectively. Consider keeping a journal of your symptoms—when they occur, how severe they are, how they feel and whether you get relief from prescribed medications.

Some of the side effects you may experience when taking sorafenib include:

Skin rash Developing a rash can actually mean the treatment is working effectively. Rash may cause itching, redness or peeling skin on the hands or feet, but it can also spread to other parts of the body.

Here are some tips to help reduce hand and foot rash:

• Where possible, avoid extremes in temperature, pressure or friction on the hands and feet.

• Carefully moisturize the hands and feet with thick ureabased creams that your doctor can prescribe.

• Wear socks at night after applying the moisturizer. You can also wear thin cotton gloves.

Usually, a rash develops within the first six weeks of starting a targeted treatment. (If it occurs right away, it is probably an allergic reaction.) It’s important to tell your health care team about any changes to your skin or nails, whenever they occur.

If a rash becomes severe, it may be necessary to temporarily stop cancer treatment or change the dose.

Mild rashes can be treated with a steroid cream applied to the skin. A steroid cream may help reduce the inflammation, pain and discomfort of a rash. Although you can buy some of these creams without a doctor’s prescription, it’s best to consult with a skin doctor (dermatologist).

Anyone who is taking a targeted treatment would be wise to use a sunscreen daily. Sun exposure can aggravate sensitive skin, especially if a rash has developed. The ingredient called Helioplex keeps a sunscreen from breaking down the way other products do. This ingredient is gentle on sensitive skin.

Diarrhea Take this symptom seriously. Severe diarrhea can lead to an imbalance in the body’s salts (electrolytes), which can affect functioning. Talk to your doctor about the right medication for you. Loperamide (Imodium A-D, for example) may be used. Do not treat yourself with any other drugs without talking to your doctor first.

There are a number of changes you can make to your diet that will help as well. For example, limit or avoid lactose (found in milk or cheese), insoluble fiber such as wheat bran or whole grain products, alcohol and sugary drinks. Increase your use of active yogurt culture, soluble fibers such as oats, high-potassium foods such as bananas and drinks such as Gatorade to replace lost electrolytes. Your doctor may also reduce your dose of sorafenib.

Fatigue A common side effect of cancer treatments, fatigue can be a challenge to manage. Talk to your health care team to explore what can be done. Medications such as stimulants may help, although they have their own side effects. Exercising regularly may help you cope with fatigue. Taking naps throughout the day can also make a difference in your energy level. It is very important to communicate with your health care team about how you feel in order to manage fatigue.

High blood pressure This side effect can be managed with diet and medication. Your doctor and a registered dietitian can advise you on how to manage high blood pressure.

Pain People being treated for liver cancer may experience pain in the liver or any other place in the body where the cancer has spread. Effective treatments are available and can make a big difference in your quality of life. Because certain pain relievers such as acetaminophen (Tylenol and others) may damage the liver, it is important that you tell your health care team about any pain you are experiencing rather than treat yourself with over-the-counter drugs. Don’t hesitate to report this (or any) side effect. There is no need for you to put up with pain.

Encephalopathy is an impairment in brain function. It is due to the liver’s inability to remove toxins from the body. Doctors usually treat encephalopathy with medication.

While it is important to eat enough protein every day, your doctor may ask you to spread out evenly throughout the day the amount of protein you eat. Your doctor can prescribe the right drug, and a registered dietitian can advise you on the right amount of protein for you.

Because of cirrhosis, some patients may experience fluid in the abdomen (ascites). If you develop this symptom, reducing the sodium in your diet will help decrease the buildup of fluid in the stomach and legs.

Frequently Asked Questions

Q. Is liver cancer hereditary? Can it run in the family?

A. Most liver cancers are caused by chronic (long-term) damage from hepatitis or alcohol. Damage to the liver, in the form of cirrhosis, also raises the risk of bile duct cancer. Some people inherit conditions that can lead to liver cancer. One of the most common is a disorder of iron metabolism. Bile duct cancer also may be inherited, but it is rare. People who have Lynch syndrome, which involves gene mutations, are at an increased risk of liver cancer, among other types of cancer. This genetic syndrome is also linked to cancers of the stomach, small intestine, gallbladder ducts, upper urinary tract, brain, skin and prostate. Women with Lynch syndrome also have a high risk of cancer of the endometrium (lining of the uterus) and ovaries.

Q. I’ve had hepatitis C. Should I be tested for liver cancer? What is my risk of developing it?

A. Anyone who has had the hepatitis C virus should be monitored, especially if cirrhosis has already developed. The risk of eventually developing a liver tumor is high in such situations. It’s important to realize that, depending on the type of infection, nowadays we often can cure hepatitis C with interferon (Intron A, Roferon-A and others), ribavirin (Rebetol and others) and a drug called a protease inhibitor such as boceprevir (Victrelis) or, in some cases, telaprevir (Incivek).

Q. Are the treatments the same for primary tumors (those that begin in the liver) as they are for metastatic tumors (those that spread to the liver from cancers in other parts of the body)?

A. The most common cancer in the liver is in fact a tumor that has come from another site such as the colon, stomach or breast. These metastatic tumors are treated with the specific drugs used when they are in their original place in the body. For primary liver tumors, there are different specific drugs used to treat them. Surgery is used for both primary and metastatic tumors. For primary tumors, having the option to do surgery depends on how much liver damage exists and whether the primary tumors have themselves spread to other parts of the body. In the case of tumors that have spread to the liver from different sites, surgery may be an option, depending upon the type of cancer and the number of tumors.

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This program was made possible by an educational grant from Daiichi Sankyo, Inc. and by a charitable contribution from Bayer HealthCare Pharmaceuticals and Onyx Pharmaceuticals.

Last updated February 14, 2013

The information presented in this publication is provided for your general information only. It is not intended as medical advice and should not be relied upon as a substitute for consultations with qualified health professionals who are aware of your specific situation. We encourage you to take information and questions back to your individual health care provider as a way of creating a dialogue and partnership about your cancer and your treatment.